Novel human membrane proteins and polynucleotides encoding the same

• US 20080213878A1
• Filed: 03/01/2006
• Published: 09/04/2008
• Est. Priority Date: 10/19/1999
• Status: Abandoned Application

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Sun, Hong, Sands, Arthur T., Wang, Xiaoming, Hu, Yi, Zambrowicz, Brian, Yu, Xuanchuan, Scoville, John, Wilganowski, Nathaniel L., Walke, D. Wade, Friedrich, Glenn, Friddle, Carl Johan, Hilbun, Erin, Mathur, Brian, Turner, C. Alexander, Nepomnichy, Boris, Donoho, Gregory, Nehls, Michael C., Gerhardt, Brenda, Miranda, Maricar
• Application Number:
  US11/365,756
• Publication Number:
  US 20080213878A1
• Time in Patent Office: Days
• US Class Current: 435/320.1
• CPC Class Codes: C07K 14/47 from mammals

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence of SEQ ID NO:

2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.

2. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

1, 3, 5, 8, 10, 13, 15, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 96, 98, 100, 102, 104, 106, 109, 111, 113, 115, 117, 119, 122, 124, 126, 128, 130, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 154, 157, 159, or 161.

3. An expression vector comprising the isolated nucleic acid molecule of claim 1.

6. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule encodes the amino acid sequence of SEQ ID NO:

97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.

7. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

96, 98, 100, 102, 104, 106, 117, 119, 122, 124, 130, 133, 135, 137, 139, 141, 143, 145, 147, or 157.

4. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:

2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.

5. The isolated polypeptide of claim 4, comprising the amino acid sequence of SEQ ID NO:

97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.

8. An oligonucleotide that inhibits the expression of a nucleic acid molecule that encodes an amino acid sequence of SEQ ID NO:

2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.

9. The oligonucleotide of claim 8, wherein said nucleic acid molecule encodes the amino acid sequence of SEQ ID NO:

97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.

10. An antibody that selectively binds a polypeptide comprising an amino acid sequence of SEQ ID NOS:

2, 4, 6, 9, 11, 14, 16, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 97, 99, 101, 103, 105, 107, 110, 112, 114, 116, 118, 120, 123, 125, 127, 129, 131, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 155, 158, 160, or 162.

11. The antibody claim 10, wherein said polypeptide comprises the amino acid sequence of SEQ ID NO:

97, 99, 101, 103, 105, 107, 110, 118, 120, 123, 125, 131, 134, 136, 138, 140, 142, 144, 146, 148, or 158.