Functionalized fluorescent nanocrystals, and methods for their preparation and use
First Claim
1. A functionalized fluorescent nanocrystal comprising:
- a fluorescent nanocrystal; and
a coating material comprising an electron rich heteroaromatic structure.
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Abstract
Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.
55 Citations
34 Claims
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1. A functionalized fluorescent nanocrystal comprising:
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a fluorescent nanocrystal; and a coating material comprising an electron rich heteroaromatic structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A functionalized fluorescent nanocrystal comprising:
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a fluorescent nanocrystal; and a coating material comprising a pyrrole containing compound. - View Dependent Claims (26)
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27. A method for preparing a functionalized fluorescent nanocrystal, the method comprising:
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providing a fluorescent nanocrystal; and contacting the fluorescent nanocrystal with a coating material comprising an electron rich heteroaromatic structure, to prepare a functionalized fluorescent nanocrystal. - View Dependent Claims (28, 29)
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30. A method for detecting a target species, the method comprising:
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providing a sample suspected of containing a target species; contacting the target species and at least one functionalized fluorescent nanocrystal to form a complex; exciting the complex; and detecting radiation emitted from the complex; wherein the functionalized fluorescent nanocrystal comprises a fluorescent nanocrystal and a coating material comprising an electron rich heteroaromatic structure. - View Dependent Claims (31)
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32. A method for separating materials, the method comprising:
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providing a mixture of a fluid and at least one functionalized fluorescent nanocrystal, wherein the functionalized fluorescent nanocrystal comprises a doped metal oxide fluorescent nanocrystal and a coating material comprising an electron rich heteroaromatic structure; exciting the functionalized fluorescent nanocrystal such that it has a magnetic moment; and exposing the mixture to a magnetic field to separate the functionalized fluorescent nanocrystal. - View Dependent Claims (33, 34)
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Specification