Biosynthetic platform for cardioprotective stress response in human fatal heart tissue

• US 20080214799A1
• Filed: 07/19/2007
• Published: 09/04/2008
• Est. Priority Date: 05/02/2003
• Status: Abandoned Application

• Current Assignee: Hospital For SICK Children
• Original Assignee: Hospital For SICK Children
• Inventors: Coles, John G., Takahashi, Mark, Van Arsdell, Glen S.
• Application Number:
  US11/879,819
• Publication Number:
  US 20080214799A1
• Time in Patent Office: Days
• US Class Current: 536/23.5
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/158 Expression markers

Abstract

The present invention is directed toward elucidation of a human fetal gene expression program in response to simulated ischemia/reperfusion (I/R) in order to identify molecular targets which account for the innate cardioprotection exhibited by the fetal phenotype.

Claims

1. A fetal gene expression network expressed in human fetal cardiac myocytes as a result of ischemia/reperfusion consisting essentially of:

Hs. 74615, Hs. 433989, Hs. 179573, Hs. 119129, Hs. 87409, Hs. 458104, Hs. 274464, Hs. 93913, Hs. 75636, Hs. 344080, Hs. 185973, Hs. 348389, Hs. 90998, Hs. 168159, Hs. 246381, Hs. 91299, Hs. 3094, Hs.433205, Hs.457574, Hs.8364, Hs.405944, Hs.117848, Hs.76847, Hs.102950, Hs.194019, Hs.82646, Hs.108972, Hs.154078, Hs.372513, Hs.227656, Hs.28805, and Hs.85155.

2. The fetal gene expression network of claim 1, wherein said network is associated with an apoptosis resistance phenotype.

3. The fetal gene expression network of claim 1, wherein said network is associated with repression of IL-6 signaling.