Active transdermal medicament patch
First Claim
1. An active transdermal medicament patch comprising:
- (a) a flexible, planar biocompatible substrate having on one side thereof a therapeutic face configured for releasable retention against the skin of a patient;
(b) a planar medicament matrix secured to said therapeutic face of said substrate, said medicament matrix being susceptible to permeation by medicament, and said medicament matrix effecting electrically conductive engagement with the skin of the patient when said substrate is retained thereupon;
(c) a power source carried on said substrate and electrically coupled to said medicament matrix; and
(d) voltage means carried non-removably on said substrate and driven by said power source for generating a substantially invariant voltage output during a predetermined therapy period and for applying said voltage output across said medicament matrix and the skin of the patient engaged thereby.
1 Assignment
0 Petitions
Accused Products
Abstract
An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face. Each electrically conductively engages the skin, when the substrate is retained thereon. A power source carried on the substrate is electrically coupled between the medicament matrix and a programmed microprocessor also carried on the substrate. A substantially invariant voltage presented at an output contact of the microprocessor is applied during a predetermined therapy period across the skin between the medicament matrix and the return electrode, inducing transcutaneous migration of medicament into the skin at a substantially constant rate. A light-emitting diode carried on the substrate and coupled to the microprocessor communicates that the patch is operating.
120 Citations
20 Claims
-
1. An active transdermal medicament patch comprising:
-
(a) a flexible, planar biocompatible substrate having on one side thereof a therapeutic face configured for releasable retention against the skin of a patient; (b) a planar medicament matrix secured to said therapeutic face of said substrate, said medicament matrix being susceptible to permeation by medicament, and said medicament matrix effecting electrically conductive engagement with the skin of the patient when said substrate is retained thereupon; (c) a power source carried on said substrate and electrically coupled to said medicament matrix; and (d) voltage means carried non-removably on said substrate and driven by said power source for generating a substantially invariant voltage output during a predetermined therapy period and for applying said voltage output across said medicament matrix and the skin of the patient engaged thereby. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
-
13. An active transdermal medicament patch comprising:
-
(a) a flexible, planar biocompatible substrate having on one side thereof a therapeutic face configured for releasable retention against the skin of a patient; (b) a medicament matrix secured to said therapeutic face of said substrate, said medicament matrix effecting electrically conductive engagement with the skin of the patient when said substrate is retained thereupon; (c) a power source carried on said substrate and electrically coupled to said medicament matrix; (d) a voltage regulator carried non-removably on said substrate and electrically coupled to said power source, said voltage regulator converting electrical potential from said power source into a substantially invariant voltage output of said voltage regulator; (e) a timer carried non-removably on said substrate and active during a predetermined therapy period wherein said voltage output of said voltage regulator is applied across said medicament matrix and the skin of the patient engaged thereby; and (f) activity indication means carried non-removably on said substrate for advising a user when said timer is active. - View Dependent Claims (14, 15, 16, 17)
-
-
18. An active transdermal medicament patch comprising:
-
(a) a flexible, planar biocompatible substrate having on one side thereof a therapeutic face configured for releasable retention against the skin of a patient; (b) a medicament matrix secured to said therapeutic face of said substrate, said medicament matrix effecting electrically conductive engagement with the skin of the patient when said substrate is retained thereupon; (c) a return electrode secured to said therapeutic face of said substrate, said return electrode effecting electrically conductive engagement with the skin of the patient when said substrate is retained thereupon (c) a power source carried on said substrate and electrically coupled to said medicament matrix; and (d) a programmed microprocessor carried non-removably on said substrate and having an input contact electrically coupled to said power source and an output contact electrically coupled to said return electrode, said. microprocessor converting electrical potential from said power source into a substantially invariant voltage output presented a said output contact of said microprocessor. - View Dependent Claims (19, 20)
-
Specification