Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
First Claim
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1. A method of delivering an agent or a combination of agents, for a medical condition to a mammal, comprisingapplying an applicator to a microdevice to cause the microdevice to contact an area of skin of the mammal to generate a prepared area of skin comprising a plurality of nanopores or nanochannels through the stratum corneum of the area of skin,applying a wet formulation comprising the agent the prepared area of skin, andcausing an effective amount of agent to deliver to the patient through the nanopores or nanochannels in the stratum corneum;
- wherein the applicator comprises a spring powered mechanical applicator, an ultrasound applicator, or a battery powered mechanical vibrator.
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Abstract
A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.
139 Citations
40 Claims
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1. A method of delivering an agent or a combination of agents, for a medical condition to a mammal, comprising
applying an applicator to a microdevice to cause the microdevice to contact an area of skin of the mammal to generate a prepared area of skin comprising a plurality of nanopores or nanochannels through the stratum corneum of the area of skin, applying a wet formulation comprising the agent the prepared area of skin, and causing an effective amount of agent to deliver to the patient through the nanopores or nanochannels in the stratum corneum; wherein the applicator comprises a spring powered mechanical applicator, an ultrasound applicator, or a battery powered mechanical vibrator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A kit for delivering an agent to a mammal, comprising
a microdevice comprising a structure selected from microneedles, microblades, microknives, and combinations thereof; -
a wet formulation comprising a bioactive agent; and a mechanism to provide for a driving force. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. An applicator for mechanical skin treatment comprising:
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(a) a housing having a plurality of walls defining an interior space, the interior space having an upper opening permitting selective access to the interior space of the housing, a cover member being removably couplable to the housing such that the cover is for closing the upper opening of the interior space of the housing; and (b) a plurality of microneedle head portion connected to a base portion being removably insertable into the interior space of the housing, each of the applicators being adapted for aiding a user to treat skin; wherein the plurality of the applicator including a microneedle array assembly comprising (i) the microneedle array assembly being adapted for selectively treating skin, and (ii) the microneedle assembly having a head portion and a base portion, the head portion being selectively couplable to the base portion such that the base portion is insertable into the interior space of the housing, the base portion of the microneedle array assembly having a pair of depressions, each of the depressions extending along a portion of a length of the base portion, one of the depressions being positioned opposite the other of the depressions such that the depressions are adapted for receiving finger tips of a hand of the user for inhibiting slipping of the base portion from the hand of the user of the applicator. - View Dependent Claims (36, 37, 38, 39, 40)
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Specification