Methods And Devices For Fractional Ablation Of Tissue

• US 20080214988A1
• Filed: 12/28/2007
• Published: 09/04/2008
• Est. Priority Date: 12/28/2000
• Status: Abandoned Application

• Current Assignee: Palomar Medical Technologies Incorporated (Hologic Incorporated)
• Original Assignee: Palomar Medical Technologies Incorporated (Hologic Incorporated)
• Inventors: Altshuler, Gregory B., Yaroslavsky, Ilya, Erofeev, Andrei V., Tuchin, Valery V.
• Application Number:
  US11/966,625
• Publication Number:
  US 20080214988A1
• Time in Patent Office: Days
• US Class Current: 604/21
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2017/00747 Dermatology
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00458 Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61B 2018/00714 Temperature
• CPC Class Codes: A61B 2018/207 mixing two wavelengths
• CPC Class Codes: A61B 2018/208 with multiple treatment beams not sharing a common path, e.g. non-axial or parallel
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61H 2201/10 with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
• CPC Class Codes: A61H 39/002 Using electric currents electrotherapy A61N1/32
• CPC Class Codes: A61N 1/00 Electrotherapy; Circuits therefor A61N2/00 takes precedence; irradiation apparatus A61N5/00
• CPC Class Codes: A61N 2/00 Magnetotherapy
• CPC Class Codes: A61N 2007/0008 Destruction of fat cells
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.

Claims

1. A method for treating tissue comprising:

ablating a portion of the tissue with electromagnetic radiation to form a plurality of channels extending a distance from a surface of the tissue;

delivering a chromophore through the channel; and

irradiating the chromophore with additional electromagnetic radiation.

2. The method of claim 1, wherein the chromophore is heated.

3. The method of claim 2, wherein the heat from the chromophore is dissipated predominantly through at least one thermal channel.

4. The method of claim 1, wherein the additional electromagnetic radiation initiates a photochemical reaction.

5. The method of claim 1, wherein the chromophore is carbon.

6. The method of claim 1, wherein the chromophore is a single element.

7. The method of claim 1, wherein the chromophore is a compound.

8. The method of claim 1, wherein the chromophore is a mixture.

9. The method of claim 1, wherein the chromophore is a magnetic particle.

10. The method of claim 1, wherein at least some of the chromophore is delivered to a layer of fat tissue.

11. The method of claim 10, wherein the chromophore is heated to a temperature sufficient to denature fat tissue in the layer.

12. The method of claim 1, wherein the step of delivering the chromophore further comprises delivering the chromophore in a composition that allows the chromophore to accumulate in a structure in the tissue prior to irradiating the chromophore.

13. The method of claim 1, further comprising allowing the chromophore to diffuse into the tissue prior to treatment.

14. The method of claim 1, wherein heat from the chromophore damages a hair follicle.

15. The method of claim 1, wherein heat from the chromophore damages a sebaceous follicle.

16. The method of claim 1, wherein heat from the chromophore damages dermal tissue.

17. The method of claim 1, wherein heat from the chromophore damages collagen.

18. The method of claim 1, wherein heat from the chromophore stimulates a healing response.

19. The method of claim 1, wherein heat from the chromophore stimulates biological activity.

20. The method of claim 1, wherein heat from the chromophore is sufficient to ablate surrounding tissue.

21. The method of claim 1, wherein heat from the chromophore is sufficient to coagulate surrounding tissue.

22. The method of claim 1, wherein heat from the chromophore is used in a photodynamic therapy.

23. The method of claim 1, further comprising cooling a volume of the tissue.

24. The method of claim 23, wherein the volume of tissue is cooled prior to irradiating the chromophore.

25. The method of claim 23, wherein the volume of tissue is cooled while the chromophore is irradiated.

26. The method of claim 23, wherein the volume of tissue is cooled after the chromophore is irradiated.

27. The method of claim 23, wherein the volume of tissue is cooled to a temperature less than or equal to approximately 30 degrees Celsius.

28. The method of claim 23, wherein the volume of tissue is cooled to a temperature less than or equal to approximately 5 degrees Celsius.

29. The method of claim 1, wherein the channels extend to a depth in the range of approximately 5 micrometers to 5 millimeters.

30. The method of claim 1, wherein the tissue is skin tissue and wherein the channels extend from the surface of the skin tissue to the epidermis.

31. The method of claim 1, wherein the tissue is skin tissue and wherein the channels extend from the surface of the skin tissue to the dermis.

32. The method of claim 1, wherein the tissue is skin tissue and wherein the channels extend from the surface of the skin tissue to below the dermis.

33. The method of claim 1, wherein each of the channels has a width of approximately 1 micrometer to 1 millimeters.

34. The method of claim 1, wherein each of the channels has a width of approximately 50 micrometers to 100 micrometers.

35. The method of claim 1, wherein the fill-factor of the channels in a cross-sectional area is between approximately 1 and 90 percent.

36. The method of claim 1, wherein the fill-factor of the channels in a cross-sectional area in a plane extending through the channels is between approximately 25 and 40 percent.

37. The method of claim 1, wherein the center-to-center distance between adjacent channels is between approximately 10 micrometers and 5 millimeters.

38. The method of claim 1, wherein the tissue is ablated with electromagnetic radiation having one or more wavelengths of between approximately 190 to 350 nanometers.

39. The method of claim 1, wherein the tissue is ablated with electromagnetic radiation having one or more wavelengths of between approximately 1.3 and 12 micrometers.

40. The method of claim 1, wherein the additional electromagnetic radiation has one or more wavelengths of between approximately 350 and 2000 nanometers.

41. The method of claim 1, wherein the additional electromagnetic radiation has one or more wavelengths in the visible spectrum.

42. The method of claim 1, wherein the additional electromagnetic radiation has one or more wavelengths in the infrared spectrum.

43. The method of claim 1, further comprising ablating a second portion of the tissue with electromagnetic radiation to form at least one additional channel extending a distance from a surface of the tissue.

44. The method of claim 43, wherein the at least one additional channel has dimensions different than those of the plurality of channels.

45. The method of claim 1, wherein the plurality of channels is a first plurality, the method further comprising creating a second plurality of channels.

46. The method of claim 45, wherein the channels of the second plurality have dimensions different than those of the plurality of channels.

47. The method of claim 1, wherein the plurality of channels includes at least first and second sets of channels, the channels of the first set having dimensions different than the channels of the second set.

48. The method of claim 47, wherein the channels of the first set extend to a first depth and the channels of the second set extend to a second depth that is deeper than the first depth.

49. A method for treating a volume of tissue comprising:

forming a channel in the tissue by applying a first dose of electromagnetic radiation having at least one wavelength component suitable for ablating the tissue;

delivering a chromophore into the channel; and

heating the chromophore with a second dose of electromagnetic radiation.

50. The method of claim 49, further comprising applying a second dose of energy to the tissue.

51. The method of claim 50, wherein the second dose is applied to the entire surface of the volume of tissue.

52. The method of claim 50, wherein the second dose is applied to portions of the volume of tissue to produce an array of treatment islets.

53. The method of claim 49, wherein the step of delivering a chromophore into the channel further comprises delivering at least a portion of the chromophore through the channel.

54. A method for performing a cosmetic procedure comprising:

creating a set of voids in skin tissue by applying electromagnetic radiation;

introducing a substance into the voids; and

applying energy to the substance to increase the temperature of the substance.

55. The method of claim 54, wherein the step of introducing a substance into the voids further comprises forcing at least a portion of the substance through the voids and into the skin tissue.

56. The method of claim 54, wherein the step of introducing a substance into the voids further comprises vibrating the tissue.

57. The method of claim 54, wherein the step of introducing a substance into the voids further comprises applying positive pressure to the tissue.

58. The method of claim 54, wherein the step of introducing a substance into the voids further comprises alternately applying positive and negative pressure to the tissue.

59. The method of claim 54, wherein the step of introducing a substance into the voids further comprises applying an electrical field to the tissue.

60. The method of claim 54, wherein the step of introducing a substance into the voids further comprises applying a magnetic field to the tissue.

61. The method of claim 54, wherein the step of introducing a substance into the voids further comprises manually manipulating the tissue.

62. The method of claim 54, wherein the step of introducing a substance into the voids further comprises massaging the tissue.

63. The method of claim 54, wherein the step of introducing a substance into the voids further comprises stretching the tissue.

64. The method of claim 54, wherein the step of introducing a substance into the voids further comprises alternately stretching and compressing the tissue.

65. The method of claim 54, wherein the step of introducing a substance into the voids further comprises applying a pressure wave to the surface of the tissue.

66. The method of claim 54, wherein the step of introducing a substance into the voids further comprises applying a jet containing the substance to the surface of the tissue.

67. The method of claim 66, wherein the substance is in the form of particulates.

68. The method of claim 66, wherein the substance is in the form of a liquid.

69. The method of claim 54, wherein the step of introducing a substance into the voids further comprises applying ultrasound to the surface of the tissue.

70. The method of claim 54 wherein the step of introducing a substance into the voids further comprises applying acoustic energy to the surface of the tissue.

71. The method of claim 54, further comprising applying energy to the substance to cause cavitation within the tissue.

72. The method of claim 54, further comprising heating the substance with energy.

73. The method of claim 72, wherein the energy is energy from the group of acoustic energy, magnetic energy, electrical energy, and radio energy.

74. A device for treating soft tissue comprising:

a source of optical radiation configured to generate sufficient optical radiation to ablate tissue;

an output aperture configured to emit the optical radiation onto the soft tissue in a pattern of treatment areas separated by untreated areas such that the optical radiation forms voids in the tissue at the treatment areas;

an optical path extending from the source of the optical radiation to the output aperture, and configured to deliver the optical radiation to the soft tissue;

a chromophore applicator configured to inject a chromophore into the voids formed by the optical radiation generated by the source during operation.

75. The method of claim 74, wherein the chromophore applicator is a jet configured to spray the chromophore into the voids.

76. A method for treating soft tissue with electromagnetic radiation comprising:

forming a plurality of channels in the skin tissue by applying electromagnetic radiation;

introducing a substance into the voids to alter an optical property of the skin; and

irradiating a chromophore in the tissue with additional electromagnetic radiation;

wherein the optically transmissive substance facilitates the transmission of electromagnetic radiation through the tissue and to the chromophore.