CARDIAC PACING SYSTEM, BLOOD PRESSURE REGULATING SYSTEM, AND CARDIAC DISEASE TREATMENT SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION

• US 20080215107A1
• Filed: 04/16/2008
• Published: 09/04/2008
• Est. Priority Date: 08/05/2002
• Status: Active Grant

• Current Assignee: Fujikin Incorporated, National Cerebral And Cardiovascular Center
• Original Assignee: Fujikin Incorporated, National Cardiovascular Center Japan
• Inventors: SUNAGAWA, Kenji, SUGIMACHI, Masaru, SATO, Takayuki
• Granted Patent: US 7,962,216 B2
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

A medical treating system based on biological activities characterized by biological activity sensing means for sensing biological activity information produced by biological activities and outputting a biological activity signal, calculating means for receiving, analyzing, and processing the biological activity signals from the biological activity sensing means, calculating an organism stimulation signal, and outputting the organism stimulation signal, and organism stimulating means for receiving the organism stimulation signal calculated by the calculating means and stimulating an organism according to the organism stimulation signal. A cardiac pacing system based on the treating system, a blood pressure regulating system, and a cardiac disease treating system are also disclosed.

Claims

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13. A cardiac pacing system based on biological activities, comprising:

a) at least one nerve activity sensing means which senses nerve activity of a cardiac sympathetic nerve and/or a vagal nerve, and outputs a plurality of nerve activity signals;

b) a calculating means which receives the nerve activity signals, calculates a plurality of pacing signals for a control of a heart rate by a convolution integral between an impulse response previously obtained from normal nerve activities and the nerve activity signals, and outputs the pacing signals; and

c) a pacing means which receives the pacing signals, and stimulates the heart based on the pacing signals such that heart rate is regulated.

14. The system of claim 13, wherein the pacing means is a cardiac pacemaker.

15. A blood pressure regulating system, which uses a native regulation rule to estimate at least one nerve activity in response to blood pressure changes, comprising:

a) at least one blood pressure sensing means which senses blood pressure and outputs a blood pressure signal;

b) a calculating means which receives the blood pressure signal, analyzes and processes the blood pressure signal to calculate a sympathetic nerve stimulation signal for a regulation of blood pressure by stimulation of a plurality of sympathetic nerve innervating vascular beds, and outputs the sympathetic nerve stimulation signal; and

c) a stimulating means which receives the sympathetic nerve stimulation signal, and stimulates the sympathetic nerve innervating vascular beds based on the sympathetic nerve stimulation signal such that blood pressure is regulated.

16. The system of claim 15, wherein the blood pressure sensing means is a pressure sensor.

17. The system of claim 15 wherein a site for sympathetic nerve stimulation is selected from the group consisting of sympathetic ganglia;

a surface of a spinal cord; and

at least one site in a brain.

18. A system to treat cardiac diseases based on biological activities, comprising:

a) at least one cardiovascular activity sensing means which senses cardiovascular activity information issued by a cardiovascular system, and outputs a plurality of cardiovascular activity signals;

b) a calculating means which receives the cardiovascular activity signals, analyzes and processes the cardiovascular activity signals to calculate a plurality of nerve stimulation signals, and outputs the nerve simulation signals; and

c) a nerve stimulating means which receives the nerve stimulation signals, and stimulates a nerve based on the nerve stimulation signals.