Coating for a Stent and a Method of Forming the Same

• US 20080215141A1
• Filed: 05/15/2008
• Published: 09/04/2008
• Est. Priority Date: 04/24/2001
• Status: Active Grant

• Current Assignee: Syed Faiyaz Ahmed Hossainy
• Original Assignee: Syed Faiyaz Ahmed Hossainy
• Inventors: Hossainy, Syed Faiyaz Ahmed
• Granted Patent: US 8,110,243 B2
• Time in Patent Office: Days
• US Class Current: 623/1.46
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/10 Macromolecular materials

Abstract

A coating for a stent and methods for coating a stent are provided. The coating may be used for the sustained delivery of an active ingredient or a combination of active ingredients.

Claims

1. A method of coating a stent, comprising:

forming discontinuous segments of a first polymer composition in a coating layer covering a stent substrate; and

loading a second polymer composition in the coating layer, the second polymer composition disposed between and in contact with the discontinuous segments of the first polymer composition, the second polymer composition including a solvent incapable of removing one or more of the discontinuous segments of the first polymer composition from the coating layer.

2. The method of claim 1, further comprising:

forming a sacrificial film on the stent substrate; and

forming vias in the sacrificial film,

wherein forming the discontinuous segments of the first polymer composition includes filling the vias with the first polymer composition followed by removing a portion or all of the sacrificial film using a second solvent capable of removing the sacrificial film but not the first polymer composition so that removal of the sacrificial film results in the discontinuous segments of the first polymer composition separated by gaps.

3. The method of claim 2, wherein loading the second polymer composition in the coating layer includes filling the gaps with the second polymer composition.

4. The method of claim 3, wherein after filling the gaps with the second composition, overlying segments of the second polymer composition are disposed over some or all of the discontinuous segments of the first polymer composition.

5. The method of claim 4, further comprising removing the overlying segments.

6. The method of claim 1, wherein forming the discontinuous segments of the first polymer composition includes:

forming a first film over the stent substrate, the first film made of the first polymer composition;

forming a protective film over the first film;

forming vias in the protective film to expose portions of the first film; and

removing the exposed portions of the first film using a second solvent capable of removing the first polymer composition but not the protective film so that removal of the exposed portions results in the discontinuous segments of the first polymer composition, there being gaps disposed between the discontinuous segments.

7. The method of claim 6, wherein loading the second polymer composition in the coating layer includes filling the gaps with the second composition.

8. The method of claim 7, wherein after filling the gaps with the second composition, overlying segments of the second polymer composition are disposed over some or all of the discontinuous segments of the first polymer composition.

9. The method of claim 8, further comprising removing the overlying segments.

10. The method of claim 1, further comprising forming a primer layer in contact with the stent substrate, the primer layer disposed between the stent substrate and the coating layer, the primer layer increasing the ability of the coating layer to remain attached to the stent substrate as compared to the coating layer being in contact with the stent substrate.

11. The method of claim 1, further comprising removing all of the solvent from the coating layer or allowing all of the solvent to evaporate out of the coating layer.

12. A stent coating produced in accordance with the method of claim 1, wherein some of the solvent remains in the coating layer.

13. The stent of claim 12, wherein the discontinuous segments of the first polymer composition are covered by the second polymer composition.

14. The stent of claim 12, wherein the discontinuous segments of the first polymer composition are separated by discontinuous segments of the second polymer composition.

15. A stent coating produced in accordance with the method of claim 1, wherein none of the solvent remains in the coating layer.

16. The stent of claim 15, wherein the second polymer composition covers the discontinuous segments of the first polymer composition.

17. The stent of claim 15, wherein the coating layer includes the discontinuous segments alternating with discontinuous segments of the second polymer composition.