Transdermal Botulinum Toxin Compositions
First Claim
Patent Images
1. A pharmaceutical composition comprising:
- a stabilized botulinum toxin; and
at least one enhancing agent for facilitating transdermal delivery of the botulinum toxin into a human patient by enhancing the permeability of the patient'"'"'s skin.
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Accused Products
Abstract
Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied on a patient, and may be provided in a transdermal patch.
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Citations
35 Claims
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1. A pharmaceutical composition comprising:
- a stabilized botulinum toxin; and
at least one enhancing agent for facilitating transdermal delivery of the botulinum toxin into a human patient by enhancing the permeability of the patient'"'"'s skin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- a stabilized botulinum toxin; and
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11. A pharmaceutical composition in a transdermal patch, the pharmaceutical composition comprising:
- a stabilized botulinum toxin that permeates through a human patient'"'"'s skin without permeating in significant amount through a blood vessel when the botulinum toxin interacts with an enhancing agent provided in the transdermal patch to cause a therapeutic effect of a disorder associated with exocytosis of a molecule from a cell.
- View Dependent Claims (12, 13, 14, 15)
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16. A transdermal patch, comprising a pharmaceutical composition, which comprises:
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a stabilized botulinum toxin; and
an enhancing agent that facilitates transdermal administration of the botulinum toxin in a bioactive form to a subdermal target site of a human patient without being administered to the patient'"'"'s circulatory system; andan adhesive disposed on one side of the transdermal patch to removably secure the patch to the patient'"'"'s skin. - View Dependent Claims (17, 18, 19, 20)
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Specification