Long Acting Injectable Crystal Formulations of Estradiol Metabolites and Methods of Using Same
First Claim
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1. A composition of comprising;
- an estradiol metabolite whereby the in vivo pharmacokinetics of said estradiol metabolite are manipulated by a procedure comprising one or more of chemical modification, crystal packing formation and particle size.
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Abstract
The present invention provides sustained release formulations of estradiol metabolites whereby the in vivo pharmacokinetics are manipulated by a method selected from the group consisting of chemical modification, crystal packing formation, particle size or a combination thereof. Such compositions are useful in the long-term treatment of a wide variety of diseases.
73 Citations
39 Claims
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1. A composition of comprising;
an estradiol metabolite whereby the in vivo pharmacokinetics of said estradiol metabolite are manipulated by a procedure comprising one or more of chemical modification, crystal packing formation and particle size. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 30, 31, 32, 33, 34, 35, 36, 39)
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37. An injectable sustained release composition comprising an estradiol metabolite, wherein the in vivo pharmacokinetics of said composition are manipulated by a procedure comprising one or more of chemical modification, crystal packing formation and particle size.
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38. A sustained release composition comprising a crystalline estradiol metabolite.
Specification