NON-LINEAR ROTATION RATES OF REMOTELY DRIVEN PARTICLES AND USES THEREOF
First Claim
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1. A method of detecting the presence of an analyte in a sample, comprising:
- a) contacting a particle with said sample; and
b) measuring the non-linear rotation rate of said particle in the presence or absence of said sample.
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Abstract
The present invention relates to biological sensors. In particular, the present invention relates to the use of remotely driven nonlinear rotation of particles (e.g., magnetic particles) for detection of cells such as microorganisms (e.g., bacteria and viruses). The present invention further relates to the use of remotely driven nonlinear rotation of particles for measurement of physical properties of a solution (e.g., viscosity).
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Citations
23 Claims
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1. A method of detecting the presence of an analyte in a sample, comprising:
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a) contacting a particle with said sample; and b) measuring the non-linear rotation rate of said particle in the presence or absence of said sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system, comprising
a) particles configured to bind to an analyte cell of interest; b) a device configured for rotating said particles at a rate sufficient for said particles to undergo non-linear rotation. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method, comprising
a) contacting particles with a solution comprising cells under conditions such that said particles bind to said cells; b) measuring the non-linear rotation rate of said particles over time, wherein said non-linear rotation rate is altered in response to change in concentration of said cells in said solution over time.
Specification