Human Elongase Genes, Uses Thereof, and Compounds for Modulating Same
First Claim
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1. An isolated polynucleotide sequence, comprising a polynucleotide sequence encoding a polypeptide having elongase activity which is selected from the group consisting of:
- (a) a sequence comprising SEQ ID NO;
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(b) a sequence at least 95% homologous with sequence (a);
(c) a sequence at least 98% homologous with sequence (a); and
(d) a sequence at least 99% homologous with sequence (a).
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Abstract
The present invention relates to elongase genes, their polypeptides and their control regions, and the use of such genes, polypeptides and control regions in determining compositions for use in the treatment of disease. The identified compositions regulate the expression of the elongase genes or modulate the activity of their protein products. The nucleotide and amino acid sequences are taught for ELG4, ELG6 and ELG7. The control sequences and function are taught for ELG1, ELG2, ELG3, ELG4, ELG5, ELG6 and ELG7.
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4 Claims
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1. An isolated polynucleotide sequence, comprising a polynucleotide sequence encoding a polypeptide having elongase activity which is selected from the group consisting of:
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(a) a sequence comprising SEQ ID NO;
8;(b) a sequence at least 95% homologous with sequence (a); (c) a sequence at least 98% homologous with sequence (a); and (d) a sequence at least 99% homologous with sequence (a). - View Dependent Claims (2, 3)
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4. An isolated host cell comprising a polynucleotide encoding a polypeptide sequence having elongase activity selected from the group consisting of:
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(a) a sequence comprising SEQ ID NO;
9;(b) a sequence which is at least 95% homologous with a sequence of (a); (c) a sequence which is at least 98% homologous with a sequence of (a); and (d) a sequence which is at least 99% homologous with a sequence of (a) in a host cell which is heterologous to said sequence.
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Specification