Method for diagnosis of physiological states by detecting patterns of volatile analytes
First Claim
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1. ) A method for diagnosis of a physiological or diseased state comprising the steps of:
- a) providing a sensor array comprising a plurality of distinct sensors, wherein each sensors comprises a holding material and a sensing molecule, wherein the holding material is a sol-gel derived material, wherein each distinct sensor differs from other distinct sensors in the holding material, the sensing molecule or both;
b) exposing the sensor array to a test biogas sample;
c) recording the response of a plurality of distinct sensors in the sensor array;
d) generating a pattern based on the response of the plurality of distinct sensors; and
e) comparing the pattern obtained from the test biogas sample to a pattern obtained from a control biogas sample to determine the presence or absence of a physiological or diseased state.
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Abstract
Provided is a non-invasive method for identification of non-physiological, physiological or diseased states based on the volatiles in gas or biogas samples from individuals. The method uses a sensor array comprising a plurality of distinct sensors which differ from other sensors by the sensing molecules or the sol-gel holding material composition. In response to a combination of volatiles, a pattern of responses is generated which can be correlated to particular non-physiological, physiological or diseased state.
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Citations
20 Claims
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1. ) A method for diagnosis of a physiological or diseased state comprising the steps of:
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a) providing a sensor array comprising a plurality of distinct sensors, wherein each sensors comprises a holding material and a sensing molecule, wherein the holding material is a sol-gel derived material, wherein each distinct sensor differs from other distinct sensors in the holding material, the sensing molecule or both; b) exposing the sensor array to a test biogas sample; c) recording the response of a plurality of distinct sensors in the sensor array; d) generating a pattern based on the response of the plurality of distinct sensors; and e) comparing the pattern obtained from the test biogas sample to a pattern obtained from a control biogas sample to determine the presence or absence of a physiological or diseased state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. ) A method for diagnosis of a physiological or diseased state comprising the steps of:
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a) providing a sensor array comprising a plurality of distinct sensors, wherein each sensors comprises a holding material and a sensing molecule, wherein the holding material is a sol-gel derived material, wherein each distinct sensor differs from other distinct sensors in the holding material, the sensing molecule or both; b) exposing the sensor array to a test biogas sample; c) recording the response of a plurality of distinct sensors in the sensor array; and d) subjecting the response of the plurality of distinct sensors to a predetermined rule set, wherein the predetermined rule set defines a particular physiological or diseased state, thereby identifying the presence or absence of a particular physiological or diseased state. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. ) A method for matching a test gaseous sample to a predetermined control gas sample comprising the steps of:
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a) providing a sensor array comprising a plurality of distinct sensors, wherein each sensors comprises a holding material and a sensing molecule, wherein the holding material is a sol-gel derived material, wherein each distinct sensor differs from other distinct sensors in the holding material, the sensing molecule or both; b) exposing the sensor array to a test gas sample; c) recording the response of a plurality of distinct sensors in the sensor array; and d) comparing the response from a plurality of distinct sensors from the test gas sample to the response from the predetermined control gas sample to determine whether or not the test gas sample matches the predetermined control sample. - View Dependent Claims (17, 18, 19, 20)
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Specification