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Methods, Kits and Compositions Pertaining to Combination Oligomers and Libraries for Their Preparation

  • US 20080220987A1
  • Filed: 12/26/2006
  • Published: 09/11/2008
  • Est. Priority Date: 03/09/2001
  • Status: Active Grant
First Claim
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1. A compound library comprising at least one set of terminal oligomer blocks and at least two sets of condensing oligomer blocks, wherein,(a) each set of oligomer blocks comprises two or more different oligomers;

  • (b) the oligomer blocks of each set are independently either peptide nucleic acid oligomer, PNA chimera or PNA combination oligomer,(c) the oligomer blocks are selected to comprise functional moieties that form a linker of at least three atoms in length that covalently links the oligomer blocks when a terminal oligomer block is condensed with a condensation oligomer block;

    (d) the oligomer blocks are not support bound;

    (e) the oligomer blocks do not comprise nucleobase-protecting groups;

    (f) all of the oligomer blocks of a set of condensing oligomer blocks contain the same independently detectable reporter moiety; and

    (g) all of the oligomer blocks of the at least one set of terminal oligomer blocks comprise the same quencher moiety.

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