METHOD OF OPENING RESERVOIR OF CONTAINMENT DEVICE

• US 20080221557A1
• Filed: 10/26/2007
• Published: 09/11/2008
• Est. Priority Date: 01/09/2001
• Status: Active Grant

• Current Assignee: Microchips Biotech, Inc. (Keratin Biosciences, Inc.)
• Original Assignee: MicroCHIPS Inc.
• Inventors: Cima, Michael J., Ausiello, Dennis, Langer, Robert S., Santini, John T., Sheppard, Norman F.
• Granted Patent: US 7,879,019 B2
• Time in Patent Office: Days
• US Class Current: 604/891.1
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: H01L 24/96 the devices being encapsulated in a common layer, e.g. neo-wafer or pseudo-wafer, said common layer being separable into individual assemblies after connecting
• CPC Class Codes: H01L 2924/00 Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/01004 Beryllium [Be]
• CPC Class Codes: H01L 2924/01005 Boron [B]
• CPC Class Codes: H01L 2924/01006 Carbon [C]
• CPC Class Codes: H01L 2924/01011 Sodium [Na]
• CPC Class Codes: H01L 2924/01013 Aluminum [Al]
• CPC Class Codes: H01L 2924/01015 Phosphorus [P]
• CPC Class Codes: H01L 2924/0102 Calcium [Ca]
• CPC Class Codes: H01L 2924/01027 Cobalt [Co]
• CPC Class Codes: H01L 2924/01033 Arsenic [As]
• CPC Class Codes: H01L 2924/01074 Tungsten [W]
• CPC Class Codes: H01L 2924/01075 Rhenium [Re]
• CPC Class Codes: H01L 2924/01079 Gold [Au]
• CPC Class Codes: H01L 2924/014 : Solder alloys
• CPC Class Codes: H01L 2924/12041 : LED
• CPC Class Codes: H01L 2924/12042 : LASER
• CPC Class Codes: H01L 2924/12043 : Photo diode
• CPC Class Codes: H01L 2924/14 : Integrated circuits
• CPC Class Codes: H01L 2924/1461 : MEMS
• CPC Class Codes: H01L 2924/19041 : being a capacitor
• CPC Class Codes: H01L 2924/19043 : being a resistor

Abstract

A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to said reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor.

Claims

1. A method of selectively opening a containment reservoir, comprising:

providing a device which comprises a substrate in which at least one reservoir is located and covered by a first reservoir cap; and

directing laser light to the reservoir cap to cause the reservoir cap to disintegrate or become permeable.

2. The method of claim 1, wherein the reservoir cap comprises a polymer.

3. The method of claim 1, wherein the device is an implantable medical device.

4. The method of claim 1, wherein the reservoir contains a drug.

5. The method of claim 4, wherein the drug comprises a therapeutic or prophylactic agent which is selected from the group consisting of anti-microbials, anti-allergenics, anti-inflammatories, vaccines, growth factors, carbonic anhydrase inhibitors, angiogenesis inhibitors, angiostatin, antiproliferative agents, anti-angiogenic factors, immunomodulatory agents, gene transfer vectors, cytotoxic agents, and chemotherapy medications.

6. The method of claim 1, wherein the reservoir contains a biosensor.

7. A method of selectively opening a containment reservoir, comprising:

providing a device which comprises (i) a substrate in which a plurality of reservoirs are located, and (ii) a plurality of reservoir caps, each of said reservoir caps covering one of the reservoirs;

at a first time, directing laser light to a first reservoir cap to cause the first reservoir cap to disintegrate or become permeable; and

at a second, later time, directing laser light to a second reservoir cap to cause the second reservoir cap to disintegrate or become permeable.

8. A kit of parts, comprising;

an implantable medical device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and

a laser for directing laser light to the reservoir cap to cause the reservoir cap to disintegrate or become permeable.

9. The kit of claim 8, wherein the reservoir contains a drug releasable following disintegration or permeabilization of the reservoir cap by the laser light.

10. The kit of claim 8, wherein the substrate comprises a flexible polymeric material or wherein the substrate is attached to a flexible supporting layer.

11. The kit of claim 8, wherein the laser is an ophthalmic laser.