LONG-TERM MONITORING FOR DISCRIMINATION OF DIFFERENT HEART RHYTHMS

• US 20080221633A1
• Filed: 05/22/2008
• Published: 09/11/2008
• Est. Priority Date: 10/19/2004
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: University of Washington
• Inventors: Linker, David Thor
• Granted Patent: US 8,326,407 B2
• Time in Patent Office: Days
• US Class Current: 607/5
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 2560/0456 Apparatus provided with a docking unit
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/333 Recording apparatus specially adapted therefor
• CPC Class Codes: A61B 5/335 using integrated circuit memory devices
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats
• CPC Class Codes: A61B 5/366 Detecting abnormal QRS complex, e.g. widening
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A method and a system for detection of an arrhythmia and discrimination between different types of arrhythmia to determine whether to administer an electric shock to the heart, the method comprising monitoring the electrical activity of a beating heart, selecting a number of heart beat intervals that will comprise an analysis segment; determining an instantaneous heart rate for each of the heart beat intervals with the segment; calculating the mean instantaneous heart rate for the segment; determining the variability of the instantaneous heart rates compared to a mean; using a linear combination of the mean and the non-linear value for comparison with a predetermined threshold to discriminate the type of arrhythmia to automatically decide if intervention is indicated.

Claims

1. A method for discrimination between different types of arrhythmia, the method comprising:

monitoring the electrical activity of a heart;

determining the duration of heart beat intervals of the heart;

selecting a number of heart beat intervals that will comprise an analysis segment;

calculating an instantaneous heart rate for each of the heart beat intervals in the analysis segment from the duration of the heart beat intervals;

calculating a mean instantaneous heart rate for the analysis segment;

determining a deviation from the mean instantaneous heart rate for each heart beat interval in the analysis segment;

determining a non-linear average value representing the deviation from the mean instantaneous heart rate in the analysis segment;

calculating a test result from a linear combination of the mean instantaneous heart rate and the non-linear average value; and

comparing the test result with a predetermined threshold to discriminate between different types of arrhythmia.

2. The method of claim 1, further comprising selectively intervening with the monitored heart if intervention is indicated by the step of comparing the test result with a predetermined threshold.

3. The method of claim 1, wherein the step of monitoring the electrical activity of a heart is accomplished with an implantable cardiac defibrillator.

4. The method of claim 3, further comprising applying an electrical defibrillation shock to the heart if intervention is indicated by the step of comparing the test result with a predetermined threshold.

5. The method of claim 1, wherein determining a non-linear average value representing the deviation from the mean instantaneous heart rate in the analysis segment comprises determining the median value of the deviation from the mean instantaneous heart rate.

6. The method of claim 1, wherein the step of calculating a test result comprises adding the product of first predetermined constant and the mean instantaneous heart rate by a with the product of a second predetermined constant and the non-linear average value.

7. The method of claim 6, wherein the first predetermined constant is in the range of 1.70 to 2.00 and the second predetermined constant is in the range of −

0.50 to −

0.60.

8. The method of claim 1, wherein the selected number of heart beat intervals that will comprise an analysis segment comprises between three and nineteen heart beat intervals.

9. The method of claim 1, wherein the predetermined threshold is determined by applying the method to archival data and selecting a threshold associated with the selected number of heart beat intervals comprising the analysis segment that provides a desired sensitivity.

10. The method of claim 1, wherein the step of determining the duration of heart beat intervals is accomplished by detecting the arrival times of QRS complexes associated with the heart.

11. The method of claim 10, wherein the duration of the heart beat intervals is calculated as the time between the arrival of successive R portions of the detected QRS complexes.

12. A method for automatically determining if intervention with a beating heart is indicated, the method comprising:

monitoring the electrical activity of a beating heart to detect the arrival time of QRS complex portions of the heart beat;

determining the duration of heart beat intervals from the detected arrival time of the QRS complex portions;

selecting a number of heart beat intervals to comprise an analysis segment;

calculating an instantaneous heart rate for each of the heart beat intervals in an analysis segment;

calculating a mean instantaneous heart rate for the analysis segment;

determining a deviation from the mean instantaneous heart rate for each heart beat interval in the analysis segment;

determining a non-linear average value representing the deviation from the mean instantaneous heart rate in the analysis segment;

calculating a test result from a linear combination of the mean instantaneous heart rate and the non-linear average value; and

comparing the test result with a predetermined threshold wherein if the test result exceeds the predetermined threshold then intervention is indicated.

13. The method of claim 12, further comprising selectively intervening with the monitored heart if intervention is indicated by the step of comparing the test result with a predetermined threshold.

14. The method of claim 12, wherein the step of monitoring the electrical activity of a heart is accomplished with an implantable cardiac defibrillator.

15. The method of claim 14, further comprising applying an electrical defibrillation shock to the heart if intervention is indicated by the step of comparing the test result with a predetermined threshold.

16. The method of claim 12, wherein determining a non-linear average value representing the deviation from the mean instantaneous heart rate in the analysis segment comprises determining the median value of the deviation from the mean instantaneous heart rate.

17. The method of claim 12, wherein the step of calculating a test result comprises adding the product of first predetermined constant and the mean instantaneous heart rate by a with the product of a second predetermined constant and the non-linear average value.

18. The method of claim 12, wherein the first predetermined constant is in the range of 1.70 to 2.00 and the second predetermined constant is in the range of −

0.50 to −

0.60.

19. The method of claim 12, wherein the selected number of heart beat intervals that will comprise an analysis segment comprises between three and nineteen heart beat intervals.

20. The method of claim 12, wherein the predetermined threshold is determined by applying the method to archival data and selecting a threshold associated with the selected number of heart beat intervals comprising the analysis segment that provides a desired sensitivity.