SYSTEM AND METHOD FOR MONITORING PHOTODYNAMIC THERAPY
First Claim
16. A system for monitoring photodynamic therapy of a target tissue, the target tissue containing a photosensitizing substance, the system comprising:
- a first light source configured to deliver light to the target tissue, the first light source having a wavelength capable of exciting the photosensitizing substance;
a second light source configured to deliver short duration light pulses to the target tissue for imaging;
an ultrasonic transducer for receiving photoacoustic signals generated due to optical absorption of light energy by the target tissue; and
a control unit in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals to provide an indication of optical energy deposition due to the photosensitizing substance in the target tissue and for determining an estimation of blood oxygenation in the target tissue.
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Accused Products
Abstract
A system and method for monitoring photodynamic therapy of a target tissue, where the target tissue contains a photosensitizing substance, include a first light source configured to deliver light to the target tissue, the first light source having a wavelength capable of exciting the photosensitizing substance. An ultrasonic transducer receives photoacoustic signals generated due to optical absorption of light energy by the target tissue, and a control unit in communication with the ultrasonic transducer reconstructs photoacoustic tomographic images from the received photoacoustic signals to provide an indication of optical energy deposition due to the photosensitizing substance in the target tissue.
179 Citations
26 Claims
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16. A system for monitoring photodynamic therapy of a target tissue, the target tissue containing a photosensitizing substance, the system comprising:
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a first light source configured to deliver light to the target tissue, the first light source having a wavelength capable of exciting the photosensitizing substance; a second light source configured to deliver short duration light pulses to the target tissue for imaging; an ultrasonic transducer for receiving photoacoustic signals generated due to optical absorption of light energy by the target tissue; and a control unit in communication with the ultrasonic transducer for reconstructing photoacoustic tomographic images from the received photoacoustic signals to provide an indication of optical energy deposition due to the photosensitizing substance in the target tissue and for determining an estimation of blood oxygenation in the target tissue.
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17. A method for monitoring photodynamic therapy of a target tissue, the target tissue containing a photosensitizing substance, the method comprising:
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providing a first light source for delivering light to the target tissue; exciting the photosensitizing substance in the target tissue; receiving photoacoustic signals generated due to optical absorption of light energy by the target tissue with an ultrasonic transducer; and reconstructing photoacoustic tomographic images from the received photoacoustic signals to provide an indication of optical energy deposition of the photosensitizing substance in the target tissue. - View Dependent Claims (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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21-1. The method according to claim 20, further comprising operating the first light source and the second light source at the same wavelength.
Specification