SENSOR HAVING A THIN-FILM INHIBITION LAYER, NITRIC OXIDE CONVERTER AND MONITOR
2 Assignments
0 Petitions
Accused Products
Abstract
Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.
-
Citations
46 Claims
-
1-25. -25. (canceled)
-
26. A sensor device for detecting an analyte species in a fluid sample medium, comprising:
-
(a) a substrate having a substrate surface; (b) one or more nanostructures disposed over the substrate surface; (c) one or more conducting elements in electrical communication with the nanostructure and configured to communicate with measurement circuitry; and (d) a layer coating at least a portion of the substrate surface, wherein the substrate and the nanostructures are differentially coated with said layer such that at least a portion of the nanostructures are exposed to permit interaction with the sample medium and wherein the layer inhibits at least one interaction between the substrate surface and the sample medium, so as to prevent or reduce at least one interference response of the device which would be detectable by the measurement circuitry via the one or more conducting elements in the absence of the layer. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
-
-
38. A sensor device for detecting an analyte species in a gas or liquid sample medium, comprising:
-
(a) a substrate having a substrate surface; (b) one or more nanostructures disposed over the substrate surface; (c) one or more conducting elements in electrical communication with the nanostructure and configured to communicate with measurement circuitry; and (d) a dielectric layer coating at least a portion of the substrate surface and said nanostructures to isolate said portions of the substrate surface and the nanostructures from direct chemical interaction with species in the sample medium, wherein i) the dielectric layer is configured to produce an electrical response at the nanostructure surface in response to interaction of analyte species in the sample medium with the dielectric layer, said electrical response detectable by the measurement circuitry; and ii) the dielectric layer inhibits at least one interaction between the substrate surface and the sample medium, so as to prevent or reduce at least one interference response of the device which would be detectable by the measurement circuitry in the absence of the layer. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46)
-
Specification