METHODS AND COMPOSITIONS FOR THE TREATMENT OR PROPHYLAXIS OF TENDON AND LIGAMENT INJURY

• US 20080223379A1
• Filed: 03/10/2008
• Published: 09/18/2008
• Est. Priority Date: 03/12/2007
• Status: Abandoned Application

• Current Assignee: Dobavet GmbH
• Original Assignee: Dobavet GmbH
• Inventors: Fricker, Christian, Stuker, Gerhard
• Application Number:
  US12/045,600
• Publication Number:
  US 20080223379A1
• Time in Patent Office: Days
• US Class Current: 128/898
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue

Abstract

The present application relates to methods for the treatment and/or prophylaxis of tendon diseases by administration of calcium dobesilate (2,5-dihydroxybenzosulfonate).

Claims

1. A method for the treatment and/or prophylaxis of tendon diseases in a patient in need thereof comprising administering to the patient a composition comprising an effective amount of calcium dobesilate (2,5-dihydroxybenzosulfonate).

2. The method of claim 1, wherein the tendon disease is tendinitis.

3. The method of claim 1, wherein the patient is a human or nonhuman mammal.

4. The method of claim 3, wherein the patient is a horse.

5. The method of claim 4 wherein the tendon disease is tendinitis of the superficial digital flexor tendon of the horse.

6. The method of claim 1, wherein the composition further contains a platelet aggregation inhibitor.

7. The method of claim 6, wherein the platelet aggregation inibitor is selected from acetylsalicylic acid (ASA) and a benzopyrone compound.

8. The method of claim 7, wherein the platelet aggregation inibitor is a benzopyrone compound selected from coumarin, hydroxycoumarin, rutin, monoxerutin, troxerutin, and diosnin.

9. The method of claim 1, wherein the composition further comprises one or more pharmaceutically acceptable excipients.

10. The method of claim 1, wherein the composition is formulated for oral, rectal, topical, or parenteral administration.

11. The method of claim 10, wherein the composition is formulated for oral administration.