Biocompatible fluorescent metal oxide nanoparticles
First Claim
Patent Images
1. A fluorescent metal oxide nanoparticle comprising:
- (a) a core comprising metal oxide;
(b) a polymer coating chemically linked to the core; and
(c) a plurality of fluorochromes chemically linked to the coating, wherein the nanoparticle has a molar extinction coefficient of at least 1,000,000 M−
1cm−
1, and emits fluorescent light upon illumination with light absorbable by the plurality of fluorochromes.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.
-
Citations
69 Claims
-
1. A fluorescent metal oxide nanoparticle comprising:
-
(a) a core comprising metal oxide; (b) a polymer coating chemically linked to the core; and (c) a plurality of fluorochromes chemically linked to the coating, wherein the nanoparticle has a molar extinction coefficient of at least 1,000,000 M−
1cm−
1, and emits fluorescent light upon illumination with light absorbable by the plurality of fluorochromes. - View Dependent Claims (2, 3, 4, 5, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
-
-
6. A fluorescent metal oxide nanoparticle comprising:
-
(a) a core comprising metal oxide; (b) a non-crosslinked polymer coating chemically linked to the core; and (c) from about 10 to about 300 fluorochromes chemically linked to the coating. - View Dependent Claims (7, 8)
-
-
9. A fluorescent metal oxide nanoparticle comprising:
-
(a) a core comprising metal oxide; (b) a polymer coating chemically linked to the core; and (c) a plurality of fluorochromes chemically linked to the polymer, wherein the nanoparticle, when illuminated with light of a wavelength absorbable by the plurality of fluorochromes chemically linked to the core retains at least 50% of the fluorescence obtained from substantially the same number of free fluorochromes when measured under the same conditions. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
Specification