Silicone Vesicles Containing Actives

• US 20080226708A1
• Filed: 10/25/2006
• Published: 09/18/2008
• Est. Priority Date: 11/01/2005
• Status: Abandoned Application

• Current Assignee: Dow Corning Corporation (Dow, Inc.)
• Original Assignee: Dow Corning Corporation (Dow, Inc.)
• Inventors: Thompson, James, Lin, Shaow Burn, Postiaux, Stephanie, Newton, Joanna
• Application Number:
  US12/091,185
• Publication Number:
  US 20080226708A1
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 8/14 Liposomes; Vesicles
• CPC Class Codes: A61K 8/894 modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 1/06 Lipsticks
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

Processes are disclosed for preparing silicone vesicle compositions and emulsions containing silicone vesicles, the compositions prepared therefrom, and formulated personal and healthcare products containing the silicone vesicles and emulsions compositions.

Claims

1. A process for preparing a vesicle composition comprising:

I) combining;

A) an organopolysiloxane having at least one hydrophilic substituent group,

B) a water miscible solvent,

D′

) a hydrophilic active,

to form a dispersion of the hydrophilic active,

II) combining;

A) an organopolysiloxane having at least one hydrophilic substituent group,

C) optionally, a silicone or organic oil,

D″

) a hydrophobic active,

to form a dispersion of the hydrophobic active,

III) combining the dispersion of the hydrophilic active and the dispersion of the hydrophobic active and admixing water to form vesicles.

2. The process of claim 1 where step I or step II further comprises the addition of B′

) a water miscible volatile solvent.

3. The process of claim 2 further comprising:

IV) removal of the water miscible volatile solvent.

4. The process of claim 1 wherein the organopolysiloxane is a silicone polyether having the formula:

5. The process of claim 1 wherein the organopolysiloxane is a (AB)_n block silicone polyether having the formula;

—

[R¹(R₂SiO))_x′

(R₂SiR¹O)(C_mH_2mO)_y′

]_n—

where x′ and

y′

are greater than 4, m is from 2 to 4 inclusive, n is greater than 2.

R is independently a monovalent organic group containing 1 to 20 carbons,

R¹ is a divalent hydrocarbon containing 2 to 30 carbons.

6. The process of claim 1 wherein the water miscible solvent B) is a glycol.

7. The process of claim 6 wherein the glycol is propylene glycol.

8. The process of claim 1 wherein the water miscible volatile solvent B′

) is an alcohol.

9. The process of claim 8 wherein the alcohol is ethanol or isopropanol.

10. The process of claim 1 wherein component C) is present and is a volatile methyl siloxane.

11. The process of claim 1 wherein D′

) or D″

) is a vitamin, sunscreen, fragrance, natural plant extract, or antioxidant.

12. The process of claim 1 wherein D″

is Vitamin A palmitate.

13. The process of claim 12 wherein D′

is Vitamin C.

14. A vesicle composition prepared according to the process of claims 1.

15. A personal care product comprising the vesicle composition of claim 14.

16. The personal care product of claim 13 wherein the personal care product is selected from an antiperspirant, deodorant, skin cream, skin care lotion, moisturizer, facial treatment, wrinkle remover, facial cleansers, bath oils, sunscreens, pre-shave, after-shave lotions, liquid soap, shaving soap, shaving lather, hair shampoo, hair conditioner, hair spray, mousse, permanent, hair cuticle coat, make-up, color cosmetic, foundation, blush, lipstick, lip balm, eyeliner, mascara, nail polishes, and powders.