Topical hormonal composition with systemic action
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Abstract
The present invention relates to the area of chemotherapy and more especially to the development of new galenic forms for application to the skin.
It relates more particularly to a topical hormonal composition with systemic action for the correction of progesterone deficiency in premenopausal women and for hormone replacement in menopausal women, characterized in that it contains, as the active principle, a progestogen derived from 19-nor progesterone, a vehicle permitting systemic passage of the said active principle chosen from the group comprising a solubilizing agent, an absorption promoter, a film-forming agent, a gelling agent or their mixtures, combined with or mixed with suitable excipients for production of a pharmaceutical form as a gel and/or a film.
61 Citations
24 Claims
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1-17. -17. (canceled)
- 18. A method for insuring a hormonal substitution therapy in menopaused women subjected to an estrogenotherapy for substitution, comprising applying on the skin of said women a safe but effective amount of a gel or film-forming gel, endowed with systemic activity, based on Nomegestrol, its esters or its ethers.
Specification