Solid Dispersion of Hydrophobic Bioactive
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Accused Products
Abstract
A stable composition of an amorphous component (such as a bioactive) and a carrier polymer is formed by mixing a bridging polymer with the bioactive and the carrier polymer, wherein the bridging polymer is a hydrogen bond donor to both the bioactive and the carrier polymer, thereby forming a composition in which the bioactive and the carrier polymer have less of a tendency to crystallise than if the bridging polymer were not present.
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Citations
22 Claims
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1-12. -12. (canceled)
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13. A method of forming a stable composition of a bioactive, comprising the steps of:
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(i) providing a bioactive and a carrier wherein, if they alone are mixed, at least one of them has a tendency to crystallize, (ii) mixing a bridging component with the bioactive and the carrier, wherein the bridging component forms hydrogen bonds with both the bioactive and the carrier, thereby forming a composition in which at least the bioactive has less of a tendency to crystallise than if the bridging component were not present, wherein the bridging component is a hydrogen bond donor to both the bioactive and the carrier, and wherein the carrier is polyvinylpyrrolidone and the bridging component is selected from polyhydroxypropylmethacrylate and polyacrylic acid. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification