METHOD AND SYSTEM FOR CEREBRAL OXYGENATION LEVEL MONITORING
First Claim
1. A method for measuring a plurality of absolute regional chromophore concentrations in a brain of a patient, comprising:
- placing a plurality of probe patches at a respective plurality of locations around the patient'"'"'s head, each probe patch being positioned against the skin of the head, at least one of said probe patches being positioned where the skin includes active hair follicles, each probe patch having a first infrared source-detector pair having a relatively short source-detector spacing and a second infrared source-detector pair having a relatively long source-detector spacing;
acquiring, for each source-detector pair for each of said probes, a phase measurement for each of a plurality of infrared radiation wavelengths and, for each of said plurality of infrared radiation wavelengths, a plurality of modulation frequencies; and
computing based on said phase measurements a plurality of absolute regional chromophore concentrations in the brain corresponding respectively to said plurality of probe patches.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods, systems, and related computer program products are provided for the reliable measurement of absolute chromophore concentrations in biological tissue, such as those indicative of blood oxygenation levels in the brain, based on infrared optical scanning. A plurality of probe patches is positioned at a respective plurality of locations around the patient'"'"'s head, each probe patch being positioned against the skin of the head, wherein at least one of the probe patches is positioned where the skin includes active hair follicles. Each probe patch comprises a first infrared source-detector pair having a relatively short source-detector spacing and a second infrared source-detector pair having a relatively long source-detector spacing. Phase-only measurements are acquired for each of a plurality of infrared radiation wavelengths and modulation frequencies for each source-detector pair. Absolute regional chromophore concentrations in the brain are computed based on the phase-only measurements.
34 Citations
20 Claims
-
1. A method for measuring a plurality of absolute regional chromophore concentrations in a brain of a patient, comprising:
-
placing a plurality of probe patches at a respective plurality of locations around the patient'"'"'s head, each probe patch being positioned against the skin of the head, at least one of said probe patches being positioned where the skin includes active hair follicles, each probe patch having a first infrared source-detector pair having a relatively short source-detector spacing and a second infrared source-detector pair having a relatively long source-detector spacing; acquiring, for each source-detector pair for each of said probes, a phase measurement for each of a plurality of infrared radiation wavelengths and, for each of said plurality of infrared radiation wavelengths, a plurality of modulation frequencies; and computing based on said phase measurements a plurality of absolute regional chromophore concentrations in the brain corresponding respectively to said plurality of probe patches. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
-
8. A system for facilitating patient monitoring, comprising:
-
a plurality of probe patches configured and adapted for placement at a respective plurality of locations around the patient'"'"'s head such that each probe patch is positioned against the skin of the head and such that at least one of said probe patches is positioned where the skin includes active hair follicles, wherein each probe patch comprises a first infrared source-detector pair having a relatively short source-detector spacing and a second infrared source-detector pair having a relatively long source-detector spacing; a processor configured to receive, for each source-detector pair for each of said probes, a phase measurement for each of a plurality of infrared radiation wavelengths and, for each of said plurality of infrared radiation wavelengths, a plurality of modulation frequencies, said processor being further configured to compute based on said phase measurements a plurality of absolute regional chromophore concentrations in the brain corresponding respectively to said plurality of probe patches; and a display output coupled to said processor for displaying said absolute regional chromophore concentrations to a viewer. - View Dependent Claims (9, 10, 11, 12, 13, 14)
-
-
15. A computer program product tangibly stored on a computer-readable medium for facilitating non-invasive patient monitoring, comprising:
-
computer code for receiving phase measurements corresponding to each of a plurality of infrared source-detector pairs disposed on each of a plurality of probe patches, said plurality of probe patches being positioned against the skin of a patient'"'"'s head at respective locations therearound including at least one location where the skin includes active hair follicles, said plurality of infrared source-detector pairs on each said probe patch including a first source-detector pair having a relatively short source-detector spacing and a second source-detector pair having a relatively long source-detector spacing, said phase measurements for each source-detector pair corresponding to a plurality of infrared radiation wavelengths and, for each infrared radiation wavelength, a plurality of modulation frequencies; computer code for computing based on said phase measurements a plurality of absolute regional chromophore concentrations in the brain corresponding respectively to said plurality of probe patches; and computer code for outputting said plurality of absolute regional chromophore concentrations to a viewable display. - View Dependent Claims (16, 17, 18, 19, 20)
-
Specification