Non-Evasive Method and Apparatus of Detection of Organism Tissues
First Claim
1. A dedicated apparatus for detecting changes in molecular structure of human body surface tissue and diagnosing the properties and the degree of pathologic change of a gland tumor in a corresponding region. This apparatus is comprised of:
- (1) a Fourier Transform mid-infrared spectrometer, used in conjunction with a mid-infrared fiber optics sampling attachment to conveniently acquire infrared spectral data of human body surface tissue. This data is processed by a data processor of its own and compared with a tumor database to diagnose the properties and the degree of pathologic change of the tested gland tumor;
(2) a fiber sampling attachment, connected to a fiber coupling part, wherein an ATR probe is able to acquire an subcutaneous infrared spectrum of the tumor at the body surface when placed on the body surface and in tight contact with it;
(3) a fiber coupling part, placed between the Fourier Transform infrared spectrometer and an infrared detector part. The fiber sampling attachment is fixed onto the fiber coupling part, and the fiber coupling part is comprised of two pieces of abaxial parabolic mirrors and a precise fine-tuning mechanism. This device makes the parallel light from an interferometer converge into a point with 1-3 mm, allowing it to effectively be coupled into an incident fiber of the fiber sampling attachment and for the light from an exiting fiber to effectively be coupled into the light path system. The precise fine-tuning mechanism is used for adjusting the position of the parabolic mirrors to precisely focus the infrared light;
(4) an infrared detector part, comprising an abaxial parabolic mirror, a detector and a 3-dimensional tuning holder for maximizing the collection of information acquired by the ATR probe.
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Abstract
The invention relates to a non-invasive method to diagnose the changes of molecular structures of organism tissues from body surface and a dedicated apparatus. The apparatus is comprised of a Fourier Transform infrared spectrometer and a set of additional accessories. Said additional accessories include a mid-IR fiber optics sampling attachment, a fiber coupling part, and an infrared detector part. The detection method is comprised of placing the ATR probe of the dedicated apparatus on the skin surface of a region to be tested, and scanning more than one time in which the resolution of the apparatus is 1-32 cm−1 and the range of the spectrum is 800-4000 cm−1. It is possible to detect changes in molecular structures of living biological tissues in the early stages of cancer, and testees will not feel uncomfortable during testing. The method is easy to operate, quick, accurate, and it doesn'"'"'t harm the body.
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Citations
22 Claims
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1. A dedicated apparatus for detecting changes in molecular structure of human body surface tissue and diagnosing the properties and the degree of pathologic change of a gland tumor in a corresponding region. This apparatus is comprised of:
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(1) a Fourier Transform mid-infrared spectrometer, used in conjunction with a mid-infrared fiber optics sampling attachment to conveniently acquire infrared spectral data of human body surface tissue. This data is processed by a data processor of its own and compared with a tumor database to diagnose the properties and the degree of pathologic change of the tested gland tumor; (2) a fiber sampling attachment, connected to a fiber coupling part, wherein an ATR probe is able to acquire an subcutaneous infrared spectrum of the tumor at the body surface when placed on the body surface and in tight contact with it; (3) a fiber coupling part, placed between the Fourier Transform infrared spectrometer and an infrared detector part. The fiber sampling attachment is fixed onto the fiber coupling part, and the fiber coupling part is comprised of two pieces of abaxial parabolic mirrors and a precise fine-tuning mechanism. This device makes the parallel light from an interferometer converge into a point with 1-3 mm, allowing it to effectively be coupled into an incident fiber of the fiber sampling attachment and for the light from an exiting fiber to effectively be coupled into the light path system. The precise fine-tuning mechanism is used for adjusting the position of the parabolic mirrors to precisely focus the infrared light; (4) an infrared detector part, comprising an abaxial parabolic mirror, a detector and a 3-dimensional tuning holder for maximizing the collection of information acquired by the ATR probe. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification