Method and Apparatus for Reduction of Spurious Effects on Physiological Measurements

• US 20080228084A1
• Filed: 11/09/2005
• Published: 09/18/2008
• Est. Priority Date: 11/09/2004
• Status: Abandoned Application

• Current Assignee: Cybiocare, Inc.
• Original Assignee: Cybiocare, Inc.
• Inventors: Nolet, Dany, Bedard, Michel
• Application Number:
  US11/666,938
• Publication Number:
  US 20080228084A1
• Time in Patent Office: Days
• US Class Current: 600/477
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence

Abstract

A method and apparatus for reducing motion artifact and spurious noise effects when computing estimates of values representative of at least one physiological parameter of a subject. For motion, measured motion values are compared with a motion threshold and the taking of physiological measurements used for computing the physiological parameter estimate values are either suspended until a measured motion value is under the threshold or a correction function is applied to the physiological measurements, the correction function being based on the measured motion values. As for spurious noise, physiological measurements taken while emitters are turned off are subtracted from physiological measurements taken while emitters are turned on in order to eliminate outside noise contamination.

Claims

1. A method for reducing motion artifact when computing estimates of values representative of at least one physiological parameter of a subject, comprising the steps of:

measuring a motion value;

comparing the motion value with a motion threshold,

if the compared motion value is lower than the motion threshold then taking at least one physiological measurement;

estimating the values representative of the at least one physiological parameter by applying a mathematical model to the at least one physiological measurement; and

providing the estimate of the values representative of the at least one physiological parameter.

2. A method according to claim 1, wherein the at least one physiological measurement is a reflectance value.

3. A method according to claim 2, wherein the step of taking at least one physiological measurement comprises the further steps of:

generating a probing light beam comprising at least one wavelength;

propagating the probing light beam into the skin of the subject from a propagation point;

measuring reflectance values of the probing light beam from at least two distances from the propagation point.

4. A method according to claim 2, wherein the reflectance values for a given wavelength are measured or integrated at time intervals equal to a multiple of the frequency of a parasitic signal.

5. A method for reducing motion artifact when computing estimates of values representative of at least one physiological parameter of a subject, comprising the steps of:

repeatably measuring a motion value;

comparing each motion value with a motion threshold,

a) if the compared motion value is lower than the motion threshold then

taking at least one physiological measurement;

estimating the values representative of the at least one physiological parameter by applying a mathematical model to the at least one physiological measurement; and

providing the estimates of the values representative of the at least one physiological parameter;

b) if a predetermined number of consecutive compared motion values are higher than the motion threshold then providing a warning to the subject.

6. A method according to claim 5, wherein the at least one physiological measurement is a reflectance value.

7. A method according to claim 6, wherein the step of taking at least one physiological measurement comprises the further steps of:

generating a probing light beam comprising at least one wavelength;

propagating the probing light beam into the skin of the subject from a propagation point;

measuring reflectance values of the probing light beam from at least two distances from the propagation point.

8. A method according to claim 7, wherein the reflectance values for a given wavelength are measured or integrated at time intervals equal to a multiple of the frequency of a parasitic signal.

9. A method for reducing motion artifact when computing estimates of values representative of at least one physiological parameter of a subject, comprising the steps of:

measuring a motion value;

taking at least one physiological measurement;

applying a correction function to the at least one physiological measurement, the correction function being based on the measured motion value;

estimating the values representative of the at least one physiological parameter by applying a mathematical model to the at least one corrected physiological measurement; and

providing the estimates of the values representative of the at least one physiological parameter.

10. A method according to claim 9, wherein the at least one physiological measurement is a reflectance value.

11. A method according to claim 10, wherein the step of taking at least one physiological measurement comprises the further steps of:

generating at a probing light beam comprising at least one wavelength;

propagating the probing light beam into the skin of the subject from a propagation point;

measuring reflectance values of the probing light beam from at least two distances from the propagation point.

12. A method according to claim 11, wherein the reflectance values for a given wavelength are measured or integrated at time intervals equal to a multiple of the frequency of a parasitic signal.

13. A method according to claim 9, wherein the correction function is set by:

incrementally applying motion;

taking at least one physiological measurement;

measuring a motion value associated with the at least one physiological measurement;

comparing each motion value with a motion threshold, if the compared motion value is higher than the motion threshold then compute the correction function using the physiological measurements with associated measured motion values and a numerical analysis method.

14. A method according to claim 13, wherein the numerical analysis method is taken from a group consisting of cubic splines and linear regressions.

15. A method for reducing spurious noise when computing estimates of values representative of at least one physiological parameter of a subject, comprising the steps of:

generating a probing signal comprising at least one wavelength;

propagating the probing signal from a propagation point;

measuring reflectance values of the probing signal for a subset of the at least one wavelength from at least two distances from the propagation point;

shutting off the probing signal for the subset of the at least one wavelength;

measuring a shut-off reflectance value from the at least two distances from the propagation point;

computing adjusted reflectance values by subtracting the shut-off reflectance values from the reflectance values;

estimating the values representative of the at least one physiological parameter by applying a mathematical model to adjusted reflectance values; and

providing the estimates of the values representative of the at least one physiological parameter.

16. A method according to claim 15, wherein the subset of the at least one wavelength comprises all of the wavelengths.

17. A method according to claim 15, wherein the probing signal is a probing light beam.

18. A method according to claim 15, wherein the probing signal is a probing radio frequency.

19. A method according to claim 15, wherein the reflectance values and the shut-off reflectance values for a given wavelength are measured or integrated at time intervals equal to a multiple of the frequency of a parasitic signal.

20. An apparatus for reducing motion artifact when computing estimates of values representative of at least one physiological parameter of a subject, comprising:

emitter for propagating a probing light beam comprising at least one wavelength into the skin of the subject from a propagation point;

at least two receivers for measuring reflectance values of the probing light beam from at least two distances from the propagation point;

a motion sensor;

a display;

a microcontroller operatively connected to the at least two receivers, the motion sensor and the display, wherein the microcontroller comprises an algorithm for;

measuring a motion value using the motion sensor;

comparing the motion value with a motion threshold;

if the compared motion value is lower than the motion threshold then measuring reflectance values using the at least two receivers;

estimating the values representative of the at least one physiological parameter by applying a mathematical model to the reflectance values; and

outputting to the display the values representative of the at least one physiological parameter.

21. An apparatus according to claim 20, wherein the motion sensor is selected from a group consisting of an accelerometer, a pressure sensor and a combination of both.

22. An apparatus according to claim 20, further comprising a temperature sensor for measuring the temperature of the skin of the subject and wherein the mathematical model includes a skin temperature correction factor.

23. An apparatus according to claim 20, wherein the reflectance values are measured or integrated at time intervals equal to a multiple of the frequency of a parasitic signal.

24. An apparatus for reducing motion artifact when computing estimates of values representative of at least one physiological parameter of a subject, comprising:

emitter for propagating a probing light beam comprising at least one wavelength into the skin of the subject from a propagation point;

at least two receivers for measuring reflectance values of the probing light beam from at least two distances from the propagation point;

a motion sensor;

a display;

a microcontroller operatively connected to the at least two receivers, the motion sensor and the display, wherein the microcontroller comprises an algorithm for;

repeatably measuring a motion value using the motion sensor;

comparing each motion value with a motion threshold,

a) if the compared motion value is lower than the motion threshold then

measuring reflectance values using the at least two receivers;

estimating the values representative of the at least one physiological parameter by applying a mathematical model to the reflectance values; and

outputting to the display the values representative of the at least one physiological parameter;

b) if a predetermined number of consecutive compared motion values are higher than the motion threshold then outputting to the display a warning to the subject.

25. An apparatus according to claim 24, wherein the motion sensor is selected from a group consisting of an accelerometer, a pressure sensor and a combination of both.

26. An apparatus according to claim 24, further comprising a temperature sensor for measuring the temperature of the skin of the subject and wherein the mathematical model includes a skin temperature correction factor.

27. An apparatus according to claim 24, wherein the reflectance values are measured or integrated at time intervals equal to a multiple of the frequency of a parasitic signal.

28. An apparatus for reducing spurious noise when computing estimates of values representative of at least one physiological parameter of a subject, comprising:

emitter for propagating a probing signal comprising at least one wavelength into the skin of the subject from a propagation point;

at least two receivers for measuring reflectance values of the probing light beam from at least two distances from the propagation point;

a display;

a microcontroller operatively connected to the at least two receivers and the display, wherein the microcontroller comprises an algorithm for;

measuring reflectance values for a subset of the at least one wavelength using the at least two receivers;

shutting off the probing signal for the subset of the at least one wavelength;

measuring shut-off reflectance values using the at least two receivers;

computing adjusted reflectance values by subtracting the shut-off reflectance values from the reflectance values;

estimating the values representative of the at least one physiological parameter by applying a mathematical model to the adjusted reflectance values; and

outputting to the display the values representative of the at least one physiological parameter.

29. An apparatus according to claim 28, wherein the subset of the at least one wavelength comprises all of the wavelengths.

30. An apparatus according to claim 28, wherein the emitter propagates light and the probing signal is a probing light beam.

31. An apparatus according to claim 28, wherein the emitter propagates radio frequencies and the probing signal is a probing radio frequency.

32. An apparatus according to claim 28, further comprising a temperature sensor for measuring the temperature of the skin of the subject and wherein the mathematical model includes a skin temperature correction factor.

33. An apparatus according to claim 28, wherein the reflectance values are measured or integrated at time intervals equal to a multiple of the frequency of a parasitic signal.