Microdialysis Probe with a Spiral Line

• US 20080228131A1
• Filed: 11/15/2007
• Published: 09/18/2008
• Est. Priority Date: 10/04/2002
• Status: Active Grant

• Current Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Original Assignee: Disetronic Licensing Ag
• Inventors: Heiniger, Hanspeter, Wright, Gavin, Haueter, Ulrich, Reihl, Bruno
• Granted Patent: US 7,828,763 B2
• Time in Patent Office: Days
• US Class Current: 604/29
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14528 invasively

Abstract

A microdialysis probe with a probe body, a probe needle for introduction into a tissue, an inlet line and an outlet line for a perfusion solution and a dialysis membrane, wherein at least one hollow channel forms the outlet line and extends at least partly spirally about the probe needle on an external surface of the probe needle. The inlet for the perfusion solution may also be in the form of spiral about the external surface of the probe needle.

Claims

1. A microdialysis probe with a probe body and a probe needle for introduction into a tissue, said probe comprising an inlet line and an outlet line for a perfusion solution, and a dialysis membrane, at least the outlet line comprising a channel which extends at least partly in a spiral along the probe needle.

2. The microdialysis probe according to claim 1, wherein the spiral part of the outlet line extends about the probe needle adjacent to the outer circumference of the probe needle.

6. The microdialysis probe as claimed in claim 1, wherein the inlet line comprises a channel extending inside the probe needle and through the spiral portion of the channel forming the outlet line.

7. The microdialysis probe as claimed in claim 2, wherein the inlet line comprises a channel extending in a spiral adjacent to the outer circumference of the probe needle and generally alongside the channel for the outlet line.

8. The microdialysis probe as claimed in claim 7, wherein the dialysis membrane is provided at least a portion of the surface of the spiral portion of the channels comprising the inlet line and outlet lines.

9. The microdialysis probe as claimed in claim 1, wherein the dialysis membrane is a hollow fiber which forms at least the channel for the outlet line.

10. The microdialysis probe as claimed in claim 1, further comprising a tip, wherein the channel for at least the outlet line is formed by a single dialysis membrane in the form of a hollow fiber which makes a reverse turn near the tip.

11. The microdialysis probe as claimed in claim 1, wherein the probe needle is formed by a cylindrical support body which, on an outer circumferential surface, has at least one recess open to the outside and extending in a spiral around at least part of the support body.

12. The microdialysis probe as claimed in claim 11, wherein the dialysis membrane is associated with a hollow fiber over the support body, at least in the area of the recess.

13. The microdialysis probe as claimed in claim 11, wherein the dialysis membrane comprises a membrane layer over the at least one recess.

14. The microdialysis probe as claimed in claim 11, wherein the dialysis membrane overlays the outer circumference of the support body, at least in the area of the recess.

15. The microdialysis probe as claimed in claim 1, wherein the dialysis membrane substantially wraps the probe needle.

17. The microdialysis probe as claimed in claim 11, wherein the dialysis membrane substantially wraps the support body.

3. A microdialysis probe with a probe body carrying a probe needle, the probe comprising an inlet line and an outlet line for a perfusion solution and a dialysis membrane, at least a portion of the outlet line being shaped in a spiral.

4. The microdialysis probe according to claim 3, wherein the dialysis membrane is associated with the outlet line.

5. The microdialysis probe according to claim 4, wherein the dialysis membrance is associated with the spiral portion of the outlet line.