IMPLANTABLE MEDICAMENT DELIVERY DEVICE AND DELIVERY TOOL AND METHOD FOR USE THEREWITH

• US 20080228193A1
• Filed: 03/08/2008
• Published: 09/18/2008
• Est. Priority Date: 03/09/2007
• Status: Abandoned Application

• Current Assignee: Anthem Orthopaedics, LLC
• Original Assignee: Anthem Orthopaedics, LLC
• Inventors: MATITYAHU, Amir M.
• Application Number:
  US12/044,955
• Publication Number:
  US 20080228193A1
• Time in Patent Office: Days
• US Class Current: 606/99
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

An implantable medicament delivery device is disclosed for administration of a medicament to a joint. The implantable delivery device includes a filament formed of a bioabsorbable material and carrying a medicament. The material of the filament is capable of eluting the medicament. A kit for use in post operatively treating a joint of a mammalian body is also disclosed. The kit comprises a package including the bioabsorbable filament carried within the package, which bioabsorbable filament carries a medicament. Delivery tools and methods are also disclosed for implantation of the medicament delivery device.

Claims

1. An implantable medicament delivery device for administration of a medicament to a mammalian body comprising an implantable filament formed of a bioabsorbable material and carrying a medicament, the material being capable of eluting the medicament.

2. The delivery device of claim 1 wherein the medicament is impregnated in the filament.

3. The delivery device of claim 1 wherein the medicament is an analgesic.

4. The delivery device of claim 1 wherein the medicament is an anesthetic.

5. The delivery device of claim 1 wherein the medicament is an anti-inflammatory.

6. The delivery device of claim 1 wherein the medicament is a steroid.

7. The delivery device of claim 1 wherein the material is capable of eluting the medicament over a period of time.

8. The delivery device of claim 1 wherein the filament includes an end and an anchor at the end for localizing the filament to tissue being treated in the mammalian body.

9. The delivery device of claim 8 wherein the filament and anchor are formed as a unitary device.

10. The delivery device of claim 8 wherein the anchor includes a tapered cone.

11. The delivery device of claim 8 wherein the anchor includes a plurality of tapered cones concentrically disposed along an axis and joined in series.

12. The delivery device of claim 8 wherein the anchor includes a series of conical ridges tapering in diameter towards a tip.

13. The delivery device of claim 8 wherein the anchor includes a threaded portion.

14. The delivery device of claim 8 wherein the anchor includes a plurality of flexible tabs.

15. The delivery device of claim 14 wherein the plurality of flexible tabs extend proximally from a tapered cone in a circumferentially spaced-apart pattern.

16. The delivery device of claim 8 wherein the anchor is cannulated.

17. The delivery device of claim 1 wherein the filament has a portion formed from an elongate member having a first end and a second end and a diameter that decreases from the first end to the second end.

18. The delivery device of claim 1 wherein the filament includes a helical portion.

19. The delivery device of claim 18 wherein the helical portion has a first end and a second end and a diameter that reduces from the first end to the second end.

20. The delivery device of claim 18 wherein the helical portion is formed from an elongate member having a first end and a second end and a diameter that decreases from the first end to the second end.

21. The delivery device of claim 1 wherein the bioabsorbable material is a hydrophobic polysaccharide.

22. The delivery device of claim 1 wherein the bioabsorbable material is a hydrophilic polysaccharide.

23. The delivery device of claim 1 wherein the bioabsorbable material is selected from the group consisting of polylactic acid and polyglycoloic acid.

24. The delivery device of claim 1 wherein the bioabsorbable material is a copolymer of polylactide-co-glycolide.

25. The delivery device of claim 1 wherein the bioabsorbable material includes at least one of a radiopaque material or salt.

26. A delivery tool for use with an implantable device to treat a joint of a mammalian body comprising an elongate tubular member having a proximal end and a distal end and a passageway extending from the proximal end to the distal end, a penetration element having a sharpened tip slidably disposed in the passageway and moveable between a first position in which the tip is recessed within the distal end of the elongate tubular member and a second position in which the tip is at least partially extended from the distal end, the penetration element being adapted to carry the implantable device, and an actuation mechanism at least partially carried by the elongate member for moving the penetration element from the first position to the second and for delivering the implantation device from the elongate tubular member into an implanted position in the joint.

27. The delivery tool of claim 26 wherein the distal end of the elongate tubular member has an outer diameter is configured to be received within an arthroscopic port.

28. The delivery tool of claim 26 wherein the elongate tubular member has an exchangeable end configured for implanting a plurality of implantable devices.

29. A method of administering a medication to a mammalian body comprising implanting a filament into a joint of the mammalian body, the filament being formed of a bioabsorbable material and carrying a medicament, and eluting the medicament from the filament after placement of the filament in the joint to aid in healing of the mammalian body in the vicinity of the joint.

30. The method of claim 29 wherein the filament is implanted in an articular space.

31. The method of claim 29 wherein the medicament is an analgesic.

32. The method of claim 29 wherein the medicament is an anesthetic.

33. The method of claim 29 wherein the medicament is an anti-inflammatory agent.

34. The method of claim 29 wherein the medicament is a steroid.

35. A kit for use in post operatively treating a joint of a mammalian body comprising a package including a bioabsorbable filament carried within the package, the bioabsorbable filament carrying a medicament.

36. The kit of claim 35 further comprising a tool for delivery of the bioabsorbable filament to the joint.

37. The kit of claim 35 wherein the filament is hermetically sealed within a container.