Methods and Apparatus for Creating Particle Derivatives of HDL with Reduced Lipid Content
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Abstract
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
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Citations
65 Claims
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1-62. -62. (canceled)
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63. A kit comprising:
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a. a high density lipoprotein source container; b. a lipid removing agent source container; c. a mixer comprising at least one of a static mixer, vortexer, or centrifuge; d. a separator comprising at least one of an absorbent, separator, centrifuge, or charcoal column; e. an output container for storing a particle derivative of the high density lipoprotein; and
,f. a plurality of tubing and a plurality of valves for controlling the flow of high density lipoprotein from the high density lipoprotein source container and lipid removing agent from the lipid removing agent source container to the mixer, for controlling the flow of mixture of lipid removing agent, lipid, and particle derivative of the high density lipoprotein to the separator, and for controlling the flow of the particle derivative of the high density lipoprotein to the output container.
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64. A kit comprising:
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a. a high density lipoprotein source container; b. a lipid removing agent source container; c. a mixer comprising at least one of a static mixer, vortexer, or centrifuge; d. a separator comprising at least one of an absorbent, separator, centrifuge, or charcoal column; e. an output container for storing modified high density lipoprotein; and
,f. a plurality of tubing and a plurality of valves for controlling the flow of high density lipoprotein from the high density lipoprotein source container and lipid removing agent from the lipid removing agent source container to the mixer, for controlling the flow of mixture of lipid removing agent, lipid, and modified high density lipoprotein to the separator, and for controlling the flow of modified high density lipoprotein to the output container.
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65-72. -72. (canceled)
Specification