Interactive Multiple Gene Expression Map System

• US 20080232658A1
• Filed: 01/11/2006
• Published: 09/25/2008
• Est. Priority Date: 01/11/2005
• Status: Abandoned Application

• Current Assignee: University of Central Florida Research Foundation Inc. (State University System of Florida)
• Original Assignee: University of Central Florida Research Foundation Inc. (State University System of Florida)
• Inventors: Sugaya, Kiminobu, Yellanki, Srikanth, Gandhi, Balaji
• Application Number:
  US11/813,679
• Publication Number:
  US 20080232658A1
• Time in Patent Office: Days
• US Class Current: 382/128
• CPC Class Codes: G06T 2207/30024 Cell structures in vitro; Tissue sections in vitro
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

Disclosed herein is a system and method for providing remotely accessible gene expression image data. The system and method allows for increased accuracy and semi-quantitative or fully quantitative data from images by enabling the remote user to select regions of interest on a compressed image, and then conducting quantitative analysis on original images at a central location. The subject invention relates to, in one embodiment, an BVIGEM (Interactive Multiple Gene Expression Maps) system: which provides internet based software tools for the extraction of functional information from gene expression images and also to act as a repository for gene expression image data.

Claims

1. A method of providing to remote users a quantitative analysis of image data comprising:

providing an image database that is accessible remotely by a remote user, wherein said image database comprises a plurality of non-compressed images of treated tissue sections from an anatomical location;

presenting to said remote user an option of selecting an image or images from a selection of low-resolution images pertaining to a specific geometric perspective of said anatomical location;

displaying to said remote user a compressed image corresponding to a low-resolution image selected by said remote user;

presenting to said remote user the option of selecting a region of interest in said compressed image selected by said remote user;

calculating pixel value statistics of said region of interest; and

providing to said remote user said pixel value statistics.

4. The method of claim 1, wherein said treated tissue sections are treated via in-situ hybridization histochemistry.

5. The method of claim 1, wherein said plurality of non-compressed images comprises scanned autoradiographs and/or Nissl-stained treated tissue sections.

6. The method of claim 1, wherein said presenting to said remote user an option of selecting an image or images from a selection of low-resolution images pertaining to a specific geometric perspective of said anatomical location comprises construction of a 3D data set from 2D in-situ hybrization histochemistry data and presenting to the remote user a manipulatable 3D image.

7. The method of claim 1, wherein said anatomical region is a brain.

8. The method of claim 7, wherein said brain is a non-human mammal brain.

2. (canceled)

3. (canceled)

9. An interactive gene expression map viewing and processing system comprising:

a database comprising a plurality of non-compressed images of treated tissue sections;

a processor, and

a computer program product comprising

a computer readable first program module for causing said processor to display to a remote user a selection of low-resolution images of said plurality of non-compressed images;

a computer readable second program module for causing said processor to present to said remote user an option to select at least one of said selection of low-resolution images;

a computer readable third program module for causing said processor to display to said remote user a compressed image corresponding to a low-resolution image selected by said remote user;

a computer readable fourth program code module for causing said processor to present an option of selecting a region of interest of said compressed image selected by said remote user;

a computer readable fifth program code module for causing said processor to calculate pixel value statistics of said region of interest using a non-compressed image; and

a computer readable sixth program code module for causing said processor to provide to said remote user said pixel value statistics.

10. The system of claim 9, wherein said plurality of non-compressed images comprises a stack of TIFF images.

11. The system of claim 10 further comprising a computer readable seventh program code module for causing said processor to identify a TIFF image from said TIFF stack corresponding to a low-resolution image selected by said remote user.

12. The system of claim 9, wherein said compressed image is a JPEG image.

13. The system of claim 9 further comprising an eighth program code module for causing said processor to split a compressed image into tiles.

14. The system of claim 13 further comprising a ninth program code module for causing said processor to present an option to zoom into said region of interest.

15. The system of claim 14 further comprising a tenth program code module for causing said processor to download tiles corresponding to said region of interest at a selected zoom level.