DIETARY COMPOSITIONS AND METHODS OF ENHANCING LEAN BODY MASS AND EXERCISE PERFORMANCE

• US 20080233186A1
• Filed: 03/21/2008
• Published: 09/25/2008
• Est. Priority Date: 03/21/2007
• Status: Active Grant

• Current Assignee: IN Ingredients, Inc.
• Original Assignee: F.H.G. Corporation
• Inventors: Miller, Peter, Romero, Tim
• Granted Patent: US 7,850,997 B2
• Time in Patent Office: Days
• US Class Current: 424/456
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23L 33/30 Dietetic or nutritional methods, e.g. for losing weight A23L33/10 takes precedence
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/332 Promoters of weight control and weight loss
• CPC Class Codes: A23V 2250/06 Amino acid
• CPC Class Codes: A23V 2250/21 Plant extracts
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 36/87 Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
• CPC Class Codes: C07C 279/14 being further substituted by carboxyl groups

Abstract

Various compounds can be administered orally to humans or animals for the purpose of enhancing nitric oxide production. Enhancing nitric oxide production is beneficial for those looking to increase lean body mass or enhance exercise performance. Such administration can also be used for the purpose of enhancing nutrient transport for purposes of athletic performance and controlling bodyweight and body fat levels. L-Arginine and alpha amino n-Butryate work synergistically to enhance nitric oxide production and may further be coupled with either and/or a) an inhibitor of nitric oxide breakdown or b) a nitric oxide potentiators or other precursor and serve to accomplish this goal of enhance nitric oxide. The composition may be administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.

Claims

1. A composition comprising L-Arginine alpha amino n-butryate.

2. The composition of claim 1 wherein L-Arginine and alpha amino n-butryate are blended together.

3. The composition of claim 1 wherein L-Arginine and alpha amino n-butryate are chemically bonded.

4. The composition of claim 1 further comprising a nitric oxide potentiator or precursor.

5. The composition of claim 4 wherein the nitric oxide potentiator or precursor is selected from a group consisting of:

gypenosides (Gynostemma pentaphyllum), Rutaecarpine, 4-Butrybetaine, perillaldehyde Ginseng, or another derivate of L-Arginine (L-Arginine base, L-Arginine Hydrochloride, L-Arginine Pyroglutamate, Arginine Esters, L-Arginine Isocaproate, L-Arginine Alph-Ketoglutarate, and mixtures thereof or L-Citrulline (Base, L-Citrulline Malate, Citrulline Esters, L-Citrulline AICG, and mixtures thereof).

6. A composition according to claim 1 further comprising a nitric oxide breakdown inhibitor.

7. The composition of claim 6 wherein the a nitric oxide breakdown inhibitor is selected from a group consisting of:

L-Norvaline, pomegranate or an extract or a derivative thereof, blueberry or an extract or a derivative thereof, grape seed or an extract or a derivative thereof, or red wine or an extract or a derivative thereof.

8. A composition of claim 1, wherein the composition is prepared in a form selected from a group consisting of:

a powder, a liquid, a tablet, a capsule, a pill, a candy, a confection food additive or a gel cap.

9. A method of increasing the lean body mass in a mammal comprising the step of orally administering to a mammal, a therapeutically effective amount of L-Arginine and alpha amino n-butyrate.

10. A method of claim 9, further comprising the step of:

orally administering to a mammal, a composition comprising a therapeutically effective amount of L-Arginine and alpha amino n-butyrate, a nitric oxide precursor, and a nitric oxide potentiator and a nitric oxide breakdown inhibitor.

11. A composition consisting essentially of L-Arginine alpha amino n-butryate, a nitric oxide potentiator or precursor, and a nitric oxide breakdown inhibitor.

12. The composition of claim 11 wherein the nitric oxide potentiator or precursor is selected from a group consisting of gypenosides (Gynostemma pentaphyllum), Rutaecarpine, 4-Butrybetaine, perillaldehyde Ginseng, or another derivate of L-Arginine (L-Arginine base, L-Arginine Hydrochloride, L-Arginine Pyroglutamate, Arginine Esters, L-Arginine Isocaproate, L-Arginine Alph-Ketoglutarate, and mixtures thereof) or L-Citrulline (Base, L-Citrulline Malate, Citrulline Esters, L-Citrulline AICG, and mixtures thereof).

13. The composition of claim 11 wherein the a nitric oxide breakdown inhibitor is selected from a group consisting of:

L-Norvaline, pomegranate or an extract or a derivative thereof, blueberry or an extract or a derivative thereof, grape seed or an extract or a derivative thereof, or red wine or an extract or a derivative thereof.

14. A composition according to claim 11, wherein the composition is prepared in a form selected from a group consisting of:

a powder, a liquid, a tablet, a capsule, a pill, a candy, a confection food additive or a gel cap.

15. The composition of claim 11 wherein L-Arginine and alpha amino n-butryate are blended together.

16. The composition of claim 11 wherein L-Arginine and alpha amino n-butryate are chemically bonded.