NOVEL NEUROTROPHIC FACTORS
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0 Petitions
Accused Products
Abstract
The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as methods of making and methods of using the same.
44 Citations
26 Claims
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1-10. -10. (canceled)
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11. A method of activating a RET receptor tyrosine kinase, the method comprising contacting a cell expressing RET and GFRalpha3 with an amount of a dimerized protein effective to bind to a complex comprising RET and GFRalpha3 and induce dimerization and autophosphorylation of RET, wherein the dimerized protein comprises a polypeptide consisting of an amino acid sequence selected from the group consisting of amino acids 37-140 of SEQ ID NO:
- 9 (NBN
104), amino acids 39-140 of SEQ ID NO;
9 (NBN
102), and amino acids 42-140 of SEQ ID NO;
9 (NBN
99). - View Dependent Claims (13, 14, 15, 17, 18, 19, 21, 22, 23, 25, 26)
- 9 (NBN
Specification