GENERATION OF COMPOUND LIBRARIES UTILIZING MOLECULAR IMPRINTS INCLUDING A DOUBLE OR ANTI-IDIOTYPIC APPROACH
First Claim
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1. A method of producing new chemical entities comprising the steps of:
- (i) taking a chemical entity as the template to prepare a molecularly imprinted polymer (MIP),(ii) removing the template from the MIP, and(iii) using specific binding sites of the MIP to direct, or facilitate, synthesis of new chemical entities,wherein a focused compound library is generated using the MIPs by screening more than one reactant and wherein hit products are those chemical entities that are obtainable only via site directed synthesis provided by the imprinted polymer.
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Abstract
The present invention relates to a method of producing new chemical entities comprising the steps of: (i) taking a chemical entity as the template to prepare a molecularly imprinted polymer (MIP), (ii) removing the template from the MIP, (iii) using the specific binding sites of the MIP to direct, or facilitate, the syntheses of new chemical entities for the generation of compound libraries using molecularly imprinted polymers, and to a use of such compound libraries.
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Citations
21 Claims
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1. A method of producing new chemical entities comprising the steps of:
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(i) taking a chemical entity as the template to prepare a molecularly imprinted polymer (MIP), (ii) removing the template from the MIP, and (iii) using specific binding sites of the MIP to direct, or facilitate, synthesis of new chemical entities, wherein a focused compound library is generated using the MIPs by screening more than one reactant and wherein hit products are those chemical entities that are obtainable only via site directed synthesis provided by the imprinted polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification