Mechanical methods for producing substrates having selectively immobilized molecules
First Claim
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1. A method of producing an array of molecules of interest on a surface of a substrate, comprising:
- providing molecules of interest over a first surface of a substrate; and
contacting selected portions of the first surface of the first substrate with a second surface wherein contact of the selected portions of the first surface with the second surface applies a force that results in removal of molecules of interest from the selected portions of the first surface.
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Abstract
Methods, systems and substrates for providing molecules of interest in selected regions of substrates for use in analytical operations. Methods employ mechanical methods of applying force for the removal of molecules of interest from other than the desired locations on a substrate.
25 Citations
21 Claims
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1. A method of producing an array of molecules of interest on a surface of a substrate, comprising:
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providing molecules of interest over a first surface of a substrate; and contacting selected portions of the first surface of the first substrate with a second surface wherein contact of the selected portions of the first surface with the second surface applies a force that results in removal of molecules of interest from the selected portions of the first surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of producing a substrate having molecules of interest located in first selected regions thereof, comprising:
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providing a first substrate having a surface with molecules of interest disposed thereon; contacting second selected regions of the surface with a second substrate, the second selected regions being different from the first selected regions; and providing a force between the first substrate and the second substrate to remove the molecules of interest from the second selected regions. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification