FLUOROPOLYMER-BASED EMULSIONS FOR THE INTRAVENOUS DELIVERY OF FLUORINATED VOLATILE ANESTHETICS
First Claim
1. A therapeutic formulation comprising:
- an aqueous solution;
semi-fluorinated block copolymers having a hydrophilic block and a fluorophilic block;
a fluorinated therapeutic compound; and
a stabilizing additive.
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Accused Products
Abstract
The present invention provides therapeutic formulations, including therapeutic emulsions and nanoemulsions, and related methods for the delivery of fluorinated therapeutic compounds, including an important class of low boiling point perfluorinated and/or perhalogenated volatile anesthetics. Emulsion-based fluorinated volatile anesthetic formulations compatible with intravenous administration are provided that are capable of delivering and releasing amounts of fluorinated volatile anesthetic compounds effective for inducing and maintaining anesthesia in patients. Intravenous delivery of the present emulsion-based fluorinated volatile anesthetic formulations permits anesthetic levels in a patient to be selectively adjusted very rapidly and accurately without the need to hyperventilate patients and without the use of irritating agents.
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Citations
48 Claims
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1. A therapeutic formulation comprising:
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an aqueous solution; semi-fluorinated block copolymers having a hydrophilic block and a fluorophilic block; a fluorinated therapeutic compound; and a stabilizing additive. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method of administering a fluorinated therapeutic compound to a patient, said method comprising the steps of:
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providing a therapeutic formulation comprising;
an aqueous solution;semi-fluorinated block copolymers having a hydrophilic block and a fluorophilic block;
a fluorinated therapeutic compound; and
a stabilizing additive;emulsifying said therapeutic formulation, thereby making a therapeutic emulsion; and delivering said therapeutic emulsion to said patient. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A method of making a therapeutic emulsion containing a fluorinated therapeutic compound, said method comprising the steps of:
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providing a therapeutic formulation comprising;
an aqueous solution;semi-fluorinated block copolymers having a hydrophilic block and a fluorophilic block;
a fluorinated therapeutic compound; and
a perhalogenated fluorocarbon stabilizing additive; andemulsifying said therapeutic formulation, thereby making said therapeutic emulsion. - View Dependent Claims (45, 46, 47)
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48. A method of stabilizing a therapeutic emulsion containing a fluorinated therapeutic compound, said method comprising the steps of:
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providing a therapeutic formulation comprising;
an aqueous solution;semi-fluorinated block copolymers having a hydrophilic block and a fluorophilic block; and
a fluorinated therapeutic compound;adding a perhalogenated fluorocarbon stabilizing additive to said therapeutic formulation; and emulsifying said therapeutic formulation, thereby stabilizing said therapeutic emulsion.
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Specification