OCULAR IMPLANT WITH ANCHOR AND THERAPEUTIC AGENT

• US 20080234624A2
• Filed: 07/12/2004
• Published: 09/25/2008
• Est. Priority Date: 04/14/2000
• Status: Active Grant

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Gharib, Morteza, Bergheim, Olav
• Granted Patent: US 8,273,050 B2
• Time in Patent Office: Days
• US Class Current: 604/8
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: Y10S 623/905 Eye

Abstract

An ocular disorder treatment implant includes an anchor and a therapeutic agent. The implant has a body with first and second end portions. The implant is configured to transport fluid from the anterior chamber of an eye to a physiological outflow pathway of the eye. The body has at least one inlet opening at the first end portion and at least one outlet opening at the second end portion such that the inlet and outlet openings are in fluid communication and define an axis therebetween. The anchor extends substantially perpendicularly to a part of the axis between the openings, and at least one outlet opening is configured to be positioned in the physiological outflow pathway. One implant has two outlet openings, and the anchor is disposed closer to one of the outlet openings.

Claims

1. An implant for treating an ocular disorder, comprising:

a body having a first end portion and a second end portion, said implant configured to transport fluid from the anterior chamber of an eye to a physiological outflow pathway of the eye, said body comprising at least one inlet opening at the first end portion and at least one outlet opening at the second end portion such that the at least one inlet opening and the at least one outlet opening are in fluid communication and define an axis therebetween;

an anchor extending substantially perpendicularly to a part of the axis between the at least one inlet opening and the at least one outlet opening;

a therapeutic agent;

wherein the at least one outlet opening is configured to be positioned in the physiological outflow pathway.

2. The implant of claim 1, wherein the body comprises a tube.

3. The implant of claim 1, wherein the body has a lumen with an oval cross-section.

4. The implant of claim 1, wherein the at least one outlet opening comprises two outlet openings positioned in the body such that the anchor is located between a respective one of the outlet openings.

8. The implant of claim 1, wherein the at least one outlet opening comprises two outlet openings and one of the outlet openings is located substantially at an intersection between the first and second end portions.

9. The implant of claim 1, wherein said part of the axis extends substantially completely through the second end portion.

10. The implant of claim 1, wherein the at least one outlet opening comprises two outlet openings with an axis extending therethrough that is substantially parallel to said part of the axis.

14. The implant of claim 1, wherein the anchor extends on plural sides of the body.

15. The implant of claim 1, wherein the therapeutic agent is part of the body of the implant.

16. The implant of claim 1, wherein the body is coated with the therapeutic agent.

17. The implant of claim 1, wherein the body includes a first portion and a second portion that is appended from the first portion, and wherein the first portion includes a lumen and the second portion carries the therapeutic agent.

18. The implant of claim 1, wherein the at least one outlet opening comprises multiple outlet openings.

5-7. -7. (canceled)

11-13. -13. (canceled)

19. An implant for treating an ocular disorder, comprising:

a body having a first end portion and a second end portion, said implant configured to transport fluid from the anterior chamber of an eye to a physiological outflow pathway of the eye, said body comprising an inlet opening at the first end portion and two outlet openings at the second end portion such that the inlet opening and the two outlet openings are in fluid communication and define an axis therebetween;

an anchor disposed closer to one of the two outlet openings and extending substantially perpendicularly to a part of the axis between the inlet opening and outlet openings;

a therapeutic agent;

wherein at least one of the outlet openings is configured to be positioned in the physiological outflow pathway.

20. The implant of claim 19, wherein the therapeutic agent is part of the body of the implant.

21. The implant of claim 19, wherein the body is coated with the therapeutic agent.

22. The implant of claim 19, wherein the body includes a first portion and a second portion that is appended from the first portion, and wherein the first portion includes a lumen and the second portion carries the therapeutic agent.

23. The implant of claim 19, wherein the body comprises a tube.

24. The implant of claim 19, wherein the body has a lumen with an oval cross-section.

25. The implant of claim 19, wherein the two outlet openings are positioned in the body such that the anchor is located between a respective one of the outlet openings.

26. The implant of claim 19, wherein one of the outlet openings is located substantially at an intersection between the first and second end portions.

27. The implant of claim 19, wherein said part of the axis extends substantially completely through the second end portion.

28. The implant of claim 19, wherein the two outlet openings have an axis extending therethrough that is substantially parallel to said part of the axis.