PIVOTALLY ENGAGED MULTIPLE PART ELECTROTRANSPORT DRUG DELIVERY DEVICE

• US 20080234627A1
• Filed: 03/20/2008
• Published: 09/25/2008
• Est. Priority Date: 03/22/2007
• Status: Abandoned Application

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Gaston, Johannes N., Vanornum, Douglas J., Dent, Wanda
• Application Number:
  US12/052,517
• Publication Number:
  US 20080234627A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

An electrotransport device for delivering a therapeutic agent through a body surface of a patient. The device has an electronic module that can be coupled with an agent module to form the electrotransport device. The agent module has a compartment containing the therapeutic agent for delivery through the body surface by electrotransport. The agent module has a first end, and includes first agent module (AM) coupler about the first end. The electronic module has a first end and a second end corresponding to the first end and second end of the agent module. The electronic module has a first electronic module (EM) coupler about the first end of the electronic module for coupling with the first AM coupler such that as the first AM coupler matingly engages with the first EM coupler the electronic module and the agent module can be pressed together pivoting about where the first AM coupler engages the first EM coupler. The electronic module includes circuitry for electrically driving the therapeutic agent for electrotransport.

Claims

1. An electrotransport device for delivering a therapeutic agent through a body surface of a patient, the device comprising:

agent module having a first end, a second end, and including a compartment that contains the therapeutic agent for electrotransporting through the body surface, the agent module including first agent module (AM) coupler about the first end; and

electronic module having a first end and a second end corresponding to the first end and second end of the agent module, the electronic module having first electronic module (EM) coupler about the first end of the electronic module for coupling with the first AM coupler such that as the first AM coupler matingly engages with the first EM coupler the electronic module and the agent module can be pressed together pivoting about where the first AM coupler engages the first EM coupler, the electronic module including circuitry for electrically driving the therapeutic agent for electrotransport.

2. The device of claim 1, wherein the agent module is a reservoir module and the reservoir module has a reservoir as the compartment and has a second AM coupler, the electronic module has a second EM coupler for retaining the second AM coupler in coupling, and wherein one of the first AM coupler and the first EM coupler is a tongue and the other of the first AM coupler and the first EM coupler having an opening such that the tongue is inserted into the opening thereby allowing the reservoir module and the electronic module to come together in a pivoting motion.

3. The device of claim 2, wherein the tongue is located about the first end of either the agent module or the electronic module and extends in a direction that has a directional component in the direction from the second end toward the first end of the module on which the tongue is located.

4. The device of claim 2, wherein the tongue is located about the first end of either the agent module or the electronic module and extends in a direction that has a directional component in the direction from the second end toward the first end of the module on which the tongue is located and wherein the tongue has a curve or angled portion such that the curve or angled portion slides against an edge of an opening of the other of the electronic module and the agent module when said modules are pressed together in pivoting motion.

5. The device of claim 2, wherein the tongue is located about the first end of the electronic module and extends substantially toward the direction of the first end from the second end of the electronic module and wherein the tongue has a curve or angled portion such that the curve or angled portion slides against an edge of an opening of the other of the electronic module and the agent module when said modules are pressed together in pivoting motion.

6. The device of claim 2, wherein the agent module including a cutout forming a channel with channel walls, the electronic module having agent module (AM)—

facing lower cover that fits inside the channel and can matingly stack onto an electronic module (EM)-facing layer in the agent module.

7. The device of claim 2, wherein the electronic module includes a printed circuit board (PCB) having circuitry for controlling function of the device, an upper cover and an AM-facing lower cover protecting the PCB in the middle.

8. The device of claim 2, wherein the electronic module includes a printed circuit board (PCB) having circuitry for controlling function of the device, an upper cover and an AM-facing lower cover protecting the PCB in the middle and wherein electrical connectors of the PCB for connecting with the agent module are either not covered by the lower cover or connected to conductive pads in the lower cover.

9. The device of claim 2, wherein the electronic module includes a printed circuit board (PCB) having circuitry for controlling function of the device, an upper cover and an AM-facing lower cover protecting the PCB in the middle and wherein the tongue is part of the AM-facing lower cover and located about the first end thereof.

10. The device of claim 2, wherein the tongue is part of an AM-facing lower cover of the electronic module and located about the first end thereof and the agent module includes a rigid EM-facing layer supporting electrical connectors for connecting with electrical connectors from the electronic module, said rigid EM-facing layer having the opening about the first end of the agent module for receiving the tongue from the electronic module.

11. The device of claim 2, wherein the electronic module includes a printed circuit board (PCB) having circuitry for controlling function of the device, an upper cover and an AM-facing lower cover protecting the PCB in the middle, the upper cover having a polymeric material less rigid than the material of the AM-facing lower cover such that the upper cover can match the agent module to be liquid resistant.

12. The device of claim 2, wherein the agent module includes a rigid EM-facing layer having the opening for receiving the tongue about the first end of the agent module, the tongue is part of an AM-facing lower cover of the electronic module and located about the first end thereof, the tongue has a major directional component extending toward the direction of the first end of the electronic module and wherein the tongue has a curve or angled portion such that the curve or angled portion slides in the opening when the electronic module and the agent module are pressed together in pivoting motion.

13. The device of claim 2, wherein the second couplers of the electrical module and the agent module can be permanently engaged by snap-fitting together.

14. The device of claim 2 wherein the second couplers of the electrical module and the agent module are selected from barb and receptor, bulb and receptor, angled ledge and receptor, and press-fit slot insert and channel.

15. A method of making an electrotransport device for delivering a therapeutic agent through a body surface of a patient, comprising matingly engaging an insert at one end of one of an agent module and an electronic module to a receptor at the other of said modules and pressing the modules together by pivoting about where the modules matingly engage, the agent module containing a compartment including the therapeutic agent.

16. The method of claim 15, wherein the agent module has a first end and a second end, and including one or more reservoirs one of which is the compartment that contains the therapeutic agent for delivery through the body surface, the agent module including first agent module (AM) coupler about the first end, the electronic module having a first end and a second end corresponding to the first end and second end of the agent module, the electronic module including circuitry for electrically driving the therapeutic agent for electrotransport and having first electronic module (EM) coupler about the first end of the electronic module for coupling with the first AM coupler, including matingly engaging a tongue from one of the first AM coupler and the first EM coupler with an opening of the other of said couplers and pressing the electronic module and the agent module together pivoting about where the first AM coupler engages the first EM coupler.

17. The method of claim 16, comprising inserting a tongue located about the first end of either the agent module or the electronic module and which extends in a direction that has a directional component in the direction from the second end towards the first end of the module on which the tongue is located into an opening in the other of the agent module and the electronic module, the tongue having a curve or angled portion, the method further comprising sliding the curve or angled portion against an edge of the opening to move the electronic module and the agent module closer together in pivoting motion.

18. The method of claim 16, wherein the tongue is located about the first end of the electronic module and extends with a directional major component toward the direction of the first end from the second end of the electronic module and wherein the tongue has a curve or angled portion such that the curve or angled portion slide against an edge of an opening of the other of the electronic module and the agent module when said modules are pressed together in pivoting motion.

19. The method of claim 16, comprising forming in the agent module a cutout as a channel with channel walls, including in the electronic module an agent module (AM)-facing lower cover that fits inside the channel and can matingly stack onto a electronic module (EM)-facing layer in the agent module, including pivotally pressing the agent module and the electronic module together to move the AM-facing lower cover into the channel and matingly stack the AM-facing lower cover onto the EM-facing layer.

20. The method of claim 16, comprising including in the electronic module a printed circuit board (PCB) having circuitry for controlling function of the device, an upper cover and an AM-facing lower cover protecting the PCB in the middle, the upper cover having a polymeric material less rigid than the material of the AM-facing lower cover, further comprising fitting the upper cover with the agent module to be liquid resistant.

21. An electrotransport device for delivering a therapeutic agent through a body surface of a patient, the device comprising:

reservoir module having a first end, a second end, and including one or more reservoirs one of which contains the therapeutic agent for electrotransporting through the body surface, the reservoir module including a slot about the first end; and

electronic module having a first end and a second end corresponding to the first end and second end of the reservoir module, the electronic module including a tongue having a curve or angled portion about the first end for matingly engaging with the slot in the reservoir module such that the curve or angled portion slides on an edge of the slot as the electronic module and the reservoir module are pressed together to result in pivoting motion about where the tongue matingly engages the slot, the electronic module including circuitry for electrically driving the therapeutic agent for electrotransport.

22. A method of using an electrotransport device for delivering a therapeutic agent through a body surface of a patient, comprising matingly engaging an insert at one end of one of a reservoir module and an electronic module to a receptor at the other of said modules so that the modules are free to pivot and pressing the modules together by pivoting about where the modules matingly engage and applying the resulting device on a body surface of a patient for electrotransport, wherein the reservoir module containing a reservoir including the therapeutic agent.