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Method of Designing Sirnas for Gene Silencing

  • US 20080234941A1
  • Filed: 10/27/2004
  • Published: 09/25/2008
  • Est. Priority Date: 10/27/2003
  • Status: Active Grant
First Claim
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1. A method for selecting from a plurality of different siRNAs one or more siRNAs for silencing a target gene in an organism, each of said plurality of different siRNAs targeting a different target sequence in a transcript of said target gene, said method comprising(a) ranking said plurality of different siRNAs according to positional base compositions of a corresponding targeted sequence motifs in said transcript, wherein each said targeted sequence motif comprises at least a portion of the target sequence of the corresponding siRNA and/or a second sequence in a sequence region flanking said target sequence;

  • and(b) selecting one or more siRNAs from said ranked siRNAs.

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