Laboratory instrumentation information management and control network

• US 20080235055A1
• Filed: 06/13/2007
• Published: 09/25/2008
• Est. Priority Date: 07/17/2003
• Status: Abandoned Application

• Current Assignee: Ventana Medical Systems Incorporated (Roche Holding AG)
• Original Assignee: Ventana Medical Systems Incorporated (Roche Holding AG)
• Inventors: Ewoniuk, Aaron, Larson, Alain, Mattingly, Scott, Crawford, William C., Stephens, Randy, Phillips, Jack, Messick, Brian
• Application Number:
  US11/818,223
• Publication Number:
  US 20080235055A1
• Time in Patent Office: Days
• US Class Current: 705/3
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G06Q 10/10 Office automation; Time management
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis

Abstract

Described are techniques for identifying samples processed in a laboratory using harmonized identifier. A case identifier identifying a patient from whom a specimen is collected is determined. A specimen identifier associated with the specimen is determined. An entry for the specimen is recorded in a data store where the entry being associated with the case identifier and the specimen identifier. A harmonized specimen identifier including the case identifier and the specimen identifier is formed. The specimen is labeled with the harmonized specimen identifier.

Claims

1. A method for identifying samples processed in a laboratory using harmonized identifiers, the method comprising:

determining a case identifier identifying a patient from whom a specimen is collected;

determining a specimen identifier associated with the specimen;

recording in a data store an entry for the specimen, the entry being associated with the case identifier and the specimen identifier;

forming a harmonized specimen identifier including the case identifier and the specimen identifier; and

labeling the specimen with the harmonized specimen identifier.

2. The method of claim 1, further comprising:

determining a block identifier for each tissue block produced from the specimen;

recording in the data store an entry for said each tissue block, the entry being associated with the case identifier, the specimen identifier, and the block identifier;

forming a harmonized block identifier for each tissue block including the case identifier, the specimen identifier, and the block identifier; and

labeling each tissue block with the harmonized block identifier.

3. The method of claim 2, further comprising, for each tissue block:

determining a slide identifier for each slide produced from said each tissue block;

recording in the data store an entry for said each slide, the entry being associated with the case identifier, the specimen identifier, the block identifier, and the slide identifier;

forming a harmonized slide identifier for said each slide including the case identifier, the specimen identifier, the block identifier, and the slide identifier; and

labeling said each slide with the harmonized slide identifier.

4. The method of claim 1, wherein said harmonized identifiers include one or more types of harmonized identifiers, said type of harmonized identifiers comprising a harmonized slide identifier type, a harmonized block identifier type, and a harmonized specimen identifier type, each type of harmonized identifier used by consumers of said harmonized identifiers to differentiate between different samples of said each type in a workflow process of the laboratory.

5. The method of claim 1, wherein said harmonized identifiers have an associated local level of uniqueness with respect to consumers thereof to allow for identification and tracking of a sample by the consumers.

6. The method of claim 1, wherein said case identifier includes a first portion identifying a source of the specimen and a second portion including one or more alphanumeric characters representing an element in a sequence of elements.

7. The method of claim 1, wherein said specimen identifier includes one or more alphanumeric characters representing an element in a sequence of elements, each specimen associated with the case identifier having a different specimen identifier.

8. The method of claim 2, wherein said block identifier includes one or more alphanumeric characters representing an element in a sequence of elements, each tissue block associated with a same specimen having a different block identifier.

9. The method of claim 3, wherein said slide identifier includes one or more alphanumeric characters representing an element in a sequence of elements, each slide produced from a same tissue block having a different slide identifier.

10. The method of claim 3, wherein each harmonized specimen identifier, harmonized block identifier, and harmonized slide identifier are encoded in a machine readable form.

11. A method of automating information associated with biological specimens processed in a laboratory comprising the steps of:

performing accessioning for one or more specimens, said accessioning including entering case information communicated to a server, the case information identifying a patient from whom the one or more specimens are obtained;

determining a case identifier for the case information;

recording data on the server associating the case identifier with the case information and the one or more specimens;

determining a different specimen identifier for each of the one or more specimens;

recording data associating the different specimen identifier with each of the one or more specimens; and

labeling each of the one or more specimens with a harmonized specimen identifier, the harmonized specimen identifier for each specimen being formed from the case identifier and the different specimen identifier associated with said each specimen.

12. The method of claim 11, further comprising, for each of the one or more specimens:

delivering said each specimen to a grossing station;

reading, from a label on said each specimen, a harmonized specimen identifier;

communicating with the server to retrieve data indicating a number of cassettes to be produced for said each specimen based on the harmonized specimen identifier;

determining a different block identifier for each of the number of cassettes;

recording data on the server associating the different block identifier with each of the number of cassettes;

marking the number of required cassettes by labeling each cassette with a harmonized block identifier formed using the case identifier, a specimen identifier included in the harmonized specimen identifier, and the block identifier associated with said each cassette;

partitioning a number of tissue portions from said specimen in accordance with said number of cassettes; and

placing a tissue portion into each of said cassettes.

13. The method of claim 12, further comprising, for each tissue block included in one of said number of cassettes:

delivering said cassette to a cutting station;

reading, from a label on said cassette, a harmonized block identifier;

communicating with the server to retrieve data indicating a number of slides to be produced for said cassette based on the harmonized block identifier and staining information for each of said number of slides;

determining a different slide identifier for each of the number of slides;

recording data on the server associating the different slide identifier with each of the number of slides; and

marking, at said cutting station, each slide by labeling said each slide with a harmonized slide identifier formed using the case identifier, a specimen identifier and a block identifier of the harmonized block identifier, and the slide identifier, said slide label also including said staining information;

cutting a number of tissue section from said each tissue block in accordance with said number of slides; and

placing a tissue section on each of said number of slides.

14. The method of claim 12, further comprising:

obtaining chain of custody information for each specimen during processing of said each specimen at one or more workflow processing points in the laboratory.

15. The method of claim 14, further comprising:

reading a label associated with each specimen containing the harmonized specimen identifier at the grossing station; and

recording on the server tracking information and associating the tracking information with said each specimen, the tracking information including date and time information and identifying an individual performing processing at the grossing station on said each specimen.

16. The method of claim 14, wherein chain of custody information is obtained related to processing a specimen, or portion derived therefrom, in connection with at least one of:

grossing, tissue processing, embedding, cutting, staining, case assembly, coverslipping, pathologist review and archiving, and the method further includes;

recording on the server the chain of custody information and associated the chain of custody information with an appropriate workflow processing point.

17. A method of tracking specimens and samples derived from the specimens in a laboratory comprising:

determining one or more checkpoint notification times associated with a specimen, each of said checkpoint notification times being associated with a workflow processing point in the laboratory;

recording the one or more checkpoint notification times and associating the one or more checkpoint notification times with the specimen;

labeling said specimen and each sample derived from a specimen with a machine readable label including information encoded thereon used for identifying said specimen and each sample derived from said specimen;

as part of processing at a workflow processing point in the laboratory, reading the machine readable label and recording tracking information associated with one of the specimen or said each sample derived therefrom having the machine readable label, said tracking information including data identifying said workflow processing point and a time at which said one of the specimen or said each sample derived therefrom is at said workflow processing point;

determining whether a checkpoint notification is associated with the workflow processing point for said specimen;

if a checkpoint notification and checkpoint notification time are associated with the workflow processing point for said specimen and the checkpoint notification time has not arrived, recording information so that a checkpoint notification communication is not generated at the checkpoint notification time; and

if a checkpoint notification and checkpoint notification time are associated with the workflow processing point for said specimen and the checkpoint notification time arrives prior to tracking information associated with the workflow processing point being entered, generating a checkpoint notification communication.

18. The method of claim 17, further comprising:

specifying one or more default time intervals each associated with a workflow processing point; and

determining a checkpoint notification time associated with the specimen at a workflow processing point relative to a first time associated with the specimen and one of the default time intervals associated with the workflow processing point.

19. The method of claim 18, further comprising:

customizing one or more checkpoint notification times associated with a specimen by overriding a default notification time generating using the one or more default time intervals.

20. A method for generating a harmonized identifier for a sample entity processed in a laboratory comprising:

determining a node corresponding to the sample entity at a position in a hierarchical representation, each level of the hierarchical representation being associated with a workflow processing point in the laboratory, said hierarchical representation having a root node and a path formed from said root node to said node, said root node corresponding to a case identifier associated with a patient from whom the sample entity is obtained;

determining a data identifier for each node in the path other than the root node, the path including two or more nodes, each node other than the root node being associated with another sample entity from which the sample entity is obtained; and

forming a harmonized identifier for the sample entity by combining the case identifier and each data identifier associated with a node in the path other than the root node.

21. The method of claim 20, wherein the harmonized identifier is stored in a database and associated with the sample entity.

22. The method of claim 20, further comprising:

labeling a container including the sample entity with the harmonized identifier encoded in a machine readable form.

23. The method of claim 22, further comprising:

labeling the container including the sample entity with the harmonized identifier encoded in a human readable form.

24. The method of claim 20, wherein the sample entity is a tissue processed in an anatomical pathology laboratory.

25. The method of claim 22, further wherein the machine readable form includes at least one of a bar code and an encoded radio frequency identification label.

26. The method of claim 22, wherein said labeling includes marking a surface of the container.

27. The method of claim 22, wherein said labeling includes generating a label affixed to the container.

28. A method for identifying a slide processed in a laboratory, the method comprising:

determining a first identifier associated with a specimen, the first identifier including a first portion denoting a source of the specimen and a year in which the specimen is obtained, and the first identifier including a second portion denoting a next integer in a sequence;

determining a second identifier for a tissue block derived from the specimen, the second identifier being one or more alphanumeric characters;

determining a third identifier for the slide having a tissue section thereon cut from the tissue block;

forming a slide identifier for the slide by concatenating the first identifier, the second identifier and the third identifier;

recording in a data store an entry for the slide, the entry being associated with the slide identifier; and

labeling the slide with the slide identifier encoded in a machine readable form.

29. The method of claim 28, wherein the slide identifier is encoded in a selected bar code symbology.

30. The method of claim 28, wherein the slide identifier is encoded on a radio frequency identifier label affixed to said slide.