METHOD OF PREPARATION OF BIOABSORBABLE POROUS REINFORCED TISSUE IMPLANTS AND IMPLANTS THEREOF

• US 20080241213A1
• Filed: 03/31/2008
• Published: 10/02/2008
• Est. Priority Date: 03/07/2003
• Status: Abandoned Application

• Current Assignee: Dennis D. Jamiolkowski, Francois Binette, Iksoo Chun, Julia Hwang, Kelly R. Brown, Mora Carolynne Melican
• Original Assignee: Dennis D. Jamiolkowski, Francois Binette, Iksoo Chun, Julia Hwang, Kelly R. Brown, Mora Carolynne Melican
• Inventors: Chun, Iksoo, Hwang, Julia, Melican, Mora Carolynne, Brown, Kelly R., Jamiolkowski, Dennis D., Binette, Francois
• Application Number:
  US12/059,042
• Publication Number:
  US 20080241213A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A biocompatible tissue implant. The tissue implant may be bioabsorbable, and is made from a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a common solvent.

Claims

1. A tissue implant, comprising a biocompatible polymeric foam and a biocompatible polymeric reinforcement member, wherein the foam and the reinforcement member are soluble in a common solvent.

2. The implant of claim 1, wherein the polymeric foam is bioabsorbable.

3. The implant of claim 1, wherein the polymeric foam comprises a polymer selected from the group consisting of aliphatic polyesters, poly(amino acids), polyalkylenes oxalates, polyamides, tyrosine derived polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, and copolymers and blends thereof.

4. The implant of claim 1, wherein the polymeric foam comprises poly(lactide-co-caprolactone) having a mole ratio of between about 70/30 and about 55/45.

5. The implant of claim 1, wherein the polymeric foam comprises poly(lactide-co-caprolactone) having a mole ratio of about 60/40.

6. The implant of claim 1, wherein the polymeric foam comprises poly(glycolide-co-caprolactone) having a mole ratio of between 35/65 and 65/35.

7. The implant of claim 1, wherein the polymeric foam comprises poly(glycolide-co-caprolactone) having a mole ratio of about 65/35.

8. The implant of claim 1, wherein the polymeric foam comprises a blend of poly(lactide-co-caprolactone) having a mole ratio of about 60/40 and poly(glycolide-co-caprolactone) having a mole ratio of about 65/35.

9. The implant of claim 1, wherein the polymeric reinforcement member comprises a plurality of particles.

10. The implant of claim 1, wherein the polymeric reinforcement member comprises at least one sheet.

11. The implant of claim 1, wherein the polymeric reinforcement member comprises at least one fiber.

12. The implant of claim 11, wherein the fiber comprises a monofilament.

13. The implant of claim 11, wherein the fiber comprises a multifilament yarn.

14. The implant of claim 13, wherein the yarn comprises at least two filaments.

15. The implant of claim 11, wherein the fiber comprises a mesh.

16. The implant of claim 11, wherein the fiber comprises a braid.

17. The implant of claim 11, wherein the fiber comprises a surgical suture.

18. The implant of claim 11, wherein the fiber comprises a weave.

19. The implant of claim 11, wherein the fiber comprises a knit.

20. The implant of claim 11, wherein the fiber comprises a non-woven.

21. The implant of claim 15 wherein the mesh comprises a monofilament.

22. The implant of claim 16, wherein the braid comprises a monofilament.

23. The implant of claim 12, wherein the monofilament has a diameter between about 50 and about 2000 micron.

24. The implant of claim 14, wherein the mesh has a mesh density of about 20% to about 88%.

25. The implant of claim 14, wherein the mesh has a mesh density of about 20% to about 55%.

26. The implant of claim 1, wherein the polymeric reinforcement member comprises a bioabsorbable polymer.

27. The implant of claim 1, wherein the polymeric reinforcement member comprises a polymer selected from the group consisting of aliphatic polyesters, poly(amino acids), polyalkylenes oxalates, polyamides, tyrosine derived polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, and copolymers blends thereof.

28. The implant of claim 1, wherein the polymeric reinforcement member comprises a mesh, said mesh comprising a copolymer of polymerized lactide and glycolide.

29. The implant of claim 1, wherein the polymeric reinforcement member comprises a mesh, said mesh comprising poly(lactide-co-glycolide) at a 95/5 mole ratio.

30. The implant of claim 1, wherein the foam comprises an open cell structure.

31. The implant of claim 1 wherein the foam comprises a closed cell structure.

32-60. -60. (canceled)