BASIC PROCESSES TO PREPARE ANTIMICROBIAL CONTACT LENSES

• US 20080241225A1
• Filed: 03/21/2008
• Published: 10/02/2008
• Est. Priority Date: 03/31/2007
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Young, Kent, Hill, Gregory A., Rathore, Osman, Chaouk, Hassan
• Application Number:
  US12/052,795
• Publication Number:
  US 20080241225A1
• Time in Patent Office: Days
• US Class Current: 424/429
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 12/088 Heavy metals
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

This invention relates to antimicrobial lenses containing metals and methods for their production.

Claims

1. A method of preparing an ionic antimicrobial lens comprising a metal salt, wherein said method comprising the steps of

(a) treating an cured ionic lens for a sufficient period of time, with a first solution wherein the pH of said first solution is equal to the pKa of the ionic monomers, that were cured to form said ionic lens;

(b) adding a metal agent to said first solution and said cured lens after step (a)

(c) treating the lens of step (b) with a second solution comprising a salt precursor.

2. The method of claim 1 wherein the pH of the first solution is at least about one unit greater than the pKa.

3. The method of claim 1 wherein the pH of the first solution is least about two units greater than the pKa.

4. The method of claim 1 wherein the pH of the first solution is about pH 6 to about pH 8.

5. The method of claim 1 wherein the metal agent is selected from the group consisting of silver nitrate, silver triflate, or silver acetate, silver tetrafluoroborate, silver sulfate, zinc acetate, zinc sulfate, copper acetate, and copper sulfate.

6. The method of claim 1 wherein the metal agent is silver nitrate.

7. The method of claim 1 wherein the salt precursor is selected from the group consisting of sodium chloride, sodium iodide, sodium bromide, lithium chloride, lithium sulfide, sodium sulfide, potassium sulfide, potassium iodide, and sodium tetrachloro argentite.

8. The method of claim 1 wherein the salt precursor is sodium iodide.

9. The method of claim 1 wherein the ionic lens is selected from the group consisting of etafilcon A, balafilcon A, bufilcon A, deltafilcon A, droxifilcon A, phemfilcon A, ocufilicon A, perfilcon A, ocufilcon B, ocufilcon C, ocufilcon D, ocufilcon E, metafilcon A, B, vifilcon A focofilcon A, and tetrafilcon B.

10. An antimicrobial ionic lens comprising a metal salt prepared by a method comprising the steps of

(a) treating an cured ionic lens for a sufficient period of time, with a first solution wherein the pH of said first solution is equal to the pKa of the ionic monomers, that were cured to form said ionic lens;

(b) adding a metal agent to said first solution and said cured lens after step (a)

(c) treating the lens of step (b) with a second solution comprising a salt precursor.

11. The antimicrobial lens of claim 10 wherein the pH of the first solution is at least about one unit greater than the pKa.

12. The antimicrobial lens of claim 10 wherein the pH of the first solution is least about two units greater than the pKa.

13. The antimicrobial ionic lens of claim 10 wherein the pH of the first solution is about pH 8.

14. The antimicrobial ionic lens of claim 10 wherein the metal agent is selected from the group consisting of silver nitrate, silver triflate, or silver acetate, silver tetrafluoroborate, silver sulfate, zinc acetate, zinc sulfate, copper acetate, and copper sulfate.

15. The antimicrobial ionic lens of claim 10 wherein the metal agent is silver nitrate.

16. The antimicrobial ionic lens of claim 10 wherein the salt precursor is selected from the group consisting of sodium chloride, sodium iodide, sodium bromide, lithium chloride, lithium sulfide, sodium sulfide, potassium sulfide, potassium iodide, and sodium tetrachloro argentite.

17. The antimicrobial ionic lens of claim 10 wherein the salt precursor is sodium iodide.

18. The antimicrobial ionic lens of claim 10 wherein the ionic lens is selected from the group consisting of etafilcon A, balafilcon A, bufilcon A, deltafilcon A, droxifilcon A, phemfilcon A, ocufilicon A, perfilcon A, ocufilcon B, ocufilcon C, ocufilcon D, ocufilcon E, metafilcon A, B, vifilcon A focofilcon A, and tetrafilcon B.

19. The antimicrobial ionic lens of claim 10 wherein the metal salt is silver iodide.