Methods of modulating apoptosis and platelet production using variants of cytochrome c
First Claim
Patent Images
1. A method for modulating apoptosis in a cell comprising administering to said cell any one of:
- (a) an isolated oligonucleotide comprising SEQ ID NO;
1;
(b) a compliment of (a);
(c) an expression vector comprising a promoter operably linked to a sequence of (a) or (b);
or(d) an isolated peptide having the sequence of SEQ ID NO;
4.
0 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to a method for using the gene or protein containing CYCS(Gly42-Ser) to enhance cellular apoptosis. The method can be used to modulate apoptosis to treat conditions associated with an abnormal rate of apoptosis, in particular to treat conditions associated with increased cell growth, for example hyperplasia, hypertrophy, cancer, neoplasia or the like. The invention also relates to the use of the gene or protein containing CYCS(Gly42-Ser) for stimulating platelet release from megakaryocytes, and also to the treatment of thrombocytopenia using the platelets.
-
Citations
18 Claims
-
1. A method for modulating apoptosis in a cell comprising administering to said cell any one of:
-
(a) an isolated oligonucleotide comprising SEQ ID NO;
1;(b) a compliment of (a); (c) an expression vector comprising a promoter operably linked to a sequence of (a) or (b);
or(d) an isolated peptide having the sequence of SEQ ID NO;
4. - View Dependent Claims (2, 3, 4, 5)
-
-
6. The use of any one of:
-
(a) an isolated oligonucleotide comprising SEQ ID NO;
1;(b) a compliment of (a); (c) an expression vector comprising a promoter operably linked to a sequence of (a) or (b);
or(d) an isolated peptide having the sequence of SEQ ID NO;
4;in the production of a composition for modulating apoptosis in a cell. - View Dependent Claims (7, 8, 9)
-
-
10. A method for stimulating platelet release from megakaryocytes comprising administering to said megakaryocyte any one of:
-
(a) an isolated oligonucleotide comprising SEQ ID NO;
1;(b) a compliment of (a); (c) an expression vector comprising a promoter operably linked to a sequence of (a) or (b);
or(d) an isolated peptide having the sequence of SEQ ID NO;
4. - View Dependent Claims (11, 12)
-
-
13. A method for the in vivo stimulation of platelet release from megakaryocytes comprising the steps of:
-
(i) administering to said megakaryocyte any one of; (a) an isolated oligonucleotide comprising SEQ ID NO;
1;(b) a compliment of (a); (c) an expression vector comprising a promoter operably linked to a sequence of (a) or (b);
or(d) an isolated peptide having the sequence of SEQ ID NO;
4;(ii) culturing the megakaryocytes under conditions suitable for platelet release. - View Dependent Claims (14, 15, 16, 17, 18)
-
Specification