RELIABILITY IN DETERMINATION OF CLINICAL STATE OF A SUBJECT

• US 20080242955A1
• Filed: 03/30/2007
• Published: 10/02/2008
• Est. Priority Date: 03/30/2007
• Status: Abandoned Application

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Huiku, Matti, Uutela, Kimmo, Rantala, Borje, Karkas, Petri, Kymalainen, Minna
• Application Number:
  US11/693,895
• Publication Number:
  US 20080242955A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/4824 Touch or pain perception evaluation A61B5/4821 takes precedence
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The invention relates to the determination of a diagnostic index indicative of the clinical state, especially nociceptive state, of a subject. In order to improve the quality of the determination process, desired input signals derived from the subject are monitored and the quality of the process is improved based on the monitoring. This is implemented by increasing user awareness of the reliability of the index or by controlling the measurement set-up. Quality information indicative of the reliability of the current index values may be produced based on the input signals. The quality information may then be employed to give an indication of the current reliability of the index and a warning if the reliability of the diagnostic index becomes compromised.

Claims

1. A method for ascertaining the clinical state of a subject, the method comprising:

acquiring at least one physiological signal from a subject;

deriving at least one parameter sequence from at least one desired physiological signal belonging to the at least one physiological signal;

performing an index determination process, thereby to form a diagnostic index based on the at least one parameter sequence, wherein the diagnostic index serves as a measure of the clinical state of the subject and wherein the index determination process includes indicating the diagnostic index to a user;

monitoring at least one input signal, wherein the at least one input signal belongs to a group including the at least one physiological signal and the at least one parameter sequence; and

enhancing, based on the monitoring, the quality of the index determination process.

2. A method according to claim 1, wherein the enhancing includes:

producing, based on the at least one input signal, quality information indicative of the reliability of the diagnostic index; and

giving, based on the quality information, an indication of the current reliability of the diagnostic index.

3. A method according to claim 2, wherein the monitoring comprises:

determining changes occurring in a selected physiological signal belonging to the at least one physiological signal; and

defining changes occurring in a selected parameter sequence belonging to the at least one parameter sequence; and

the producing comprises

comparing the changes occurring in the selected physiological signal with the changes occurring in the selected parameter sequence; and

generating the quality information based on the comparing.

4. A method according to claim 3, wherein the determining includes determining changes occurring in the selected physiological signal, wherein the selected physiological signal is a blood pressure (BP) signal.

5. A method according to claim 3, wherein the defining includes defining changes occurring in the selected parameter sequence, wherein the selected parameter sequence is a plethysmographic amplitude (PGA) signal.

6. A method according to claim 2, wherein:

the producing includes calculating the quality information as the correlation between a selected physiological signal and a selected parameter sequence, wherein the selected physiological signal belongs to the at least one physiological signal and the selected parameter sequence belongs to the at least one parameter sequence; and

the giving includes displaying a warning message when the correlation fulfills a predetermined condition.

7. A method according to claim 2, wherein:

the monitoring includes determining an auxiliary signal based on at least one of the at least one physiological signal; and

the producing includes producing the quality information, in which the quality information represents the correlation between the auxiliary signal and a selected parameter sequence belonging to the at least one parameter sequence.

8. A method according to claim 7, wherein the producing includes producing the correlation between the auxiliary signal and the selected parameter sequence, in which the selected parameter sequence is a plethysmographic amplitude (PGA) signal.

9. A method according to claim 7, wherein the determining includes determining the auxiliary signal, in which the auxiliary signal is one of a signal representing the pulse transit time (PTT) of the subject and a signal representing the heart rate of the subject.

10. A method according to claim 7, wherein the giving includes displaying a warning message when the correlation fulfills a predetermined condition.

11. A method according to claim 2, wherein the producing includes producing the quality information, in which the quality information is a quality measure indicative of the current reliability of the diagnostic index.

12. A method according to claim 2, wherein the enhancing includes changing at least one of the at least one parameter sequence if the quality information indicates that the current reliability of the diagnostic index drops below a certain limit.

13. A method according to claim 2, wherein the enhancing includes transforming the quality information into visually interpretable symbols.

14. A method according to claim 1, wherein:

the monitoring includes monitoring the at least one physiological signal acquired from the subject; and

the enhancing includes generating an indication of the type(s) of the at least one physiological signal.

15. A method according to claim 14, wherein the enhancing further includes:

mapping the indication to a quality level; and

indicating the quality level visually to a user.

16. A method according to claim 14, wherein the enhancing further includes selecting, based on the monitoring, the at least one desired physiological signal from among the at least one physiological signal and an algorithm for the index determination process.

17. A method according to claim 16, further comprising repeating the selecting during the performing of the index determination process.

18. A method according to claim 17, wherein the repeating is performed in response to a change in the number of the at least one physiological signal.

19. An apparatus for ascertaining the clinical state of a subject, the apparatus comprising:

a measurement unit configured to acquire at least one physiological signal from a subject;

a first calculation unit configured to derive at least one parameter sequence from at least one desired physiological signal belonging to the at least one physiological signal;

a second calculation unit configured to perform an index determination process, thereby to form a diagnostic index based on the at least one parameter sequence, wherein the diagnostic index serves as a measure of the clinical state of the subject and wherein the index determination process is configured to indicate the diagnostic index to a user;

a quality enhancing module configured to monitor at least one input signal and to enhance the quality of the index determination process based on the at least one input signal, wherein the at least one input signal belongs to a group including the at least one physiological signal and the at least one parameter sequence.

20. An apparatus according to claim 19, wherein the quality enhancing module is configured to:

produce quality information indicative of the reliability of the diagnostic index; and

give, based on the quality information, an indication of the current reliability of the diagnostic index.

21. An apparatus according to claim 20, wherein the quality enhancing module is configured to:

determine changes occurring in a selected physiological signal, wherein the selected physiological signal belongs to the at least one physiological signal;

define changes occurring in a selected parameter sequence, wherein the selected parameter sequence belongs to the at least one parameter sequence; and

compare the changes occurring in the selected physiological signal with the changes occurring in the selected parameter sequence.

22. An apparatus according to claim 21, wherein the selected physiological signal is a blood pressure (BP) signal.

23. An apparatus according to claim 21, wherein the selected parameter sequence is a plethysmographic amplitude (PGA) signal.

24. An apparatus according to claim 20, wherein the quality enhancing module is configured to calculate a correlation between a selected physiological signal and a selected parameter sequence, wherein the selected physiological signal belongs to the at least one physiological signal and the selected parameter sequence belongs to the at least one parameter sequence.

25. An apparatus according to claim 20, wherein the quality enhancing module is configured to:

determine an auxiliary signal based on at least one of the at least one physiological signal;

determine changes occurring in the auxiliary signal;

define changes occurring in a selected parameter sequence, wherein the selected parameter sequence belongs to the at least one parameter sequence; and

compare the changes occurring in the auxiliary signal with the changes occurring in the selected parameter sequence.

26. An apparatus according to claim 25, wherein the selected parameter sequence is a plethysmographic amplitude (PGA) signal and the auxiliary signal is one of a signal representing the pulse transit time (PTT) of the subject and a signal representing the heart rate of the subject.

27. An apparatus according to claim 26, wherein the quality enhancing module is configured to calculate a correlation between the auxiliary signal and the selected parameter sequence.

28. An apparatus according to claim 20, wherein the quality enhancing module is configured to determine a quality measure indicative of the current reliability of the diagnostic index.

29. An apparatus according to claim 20, wherein the quality enhancing module is configured to change at least one of the at least one parameter sequence if the quality information indicates that the current reliability of the diagnostic index drops below a certain limit.

30. An apparatus according to claim 20, wherein the quality enhancing module is configured to transform the quality information into visually interpretable symbols.

31. An apparatus according to claim 19, wherein quality enhancing module is configured to:

monitor the at least one physiological signal acquired from the subject; and

generate an indication of the types of the at least one physiological signal.

32. An apparatus according to claim 31, wherein the quality enhancing module is further configured to map the indication to a quality level and to display the quality level visually to a user.

33. An apparatus according to claim 31, wherein the quality enhancing module is further configured to select the at least one desired physiological signal and an algorithm for the second calculation unit.

34. An apparatus according to claim 31, wherein the quality enhancing module is further configured to select the at least one desired physiological signal in response to a change in the number of the at least one physiological signal.

35. An apparatus for ascertaining the clinical state of a subject, the apparatus comprising:

measurement means for acquiring at least one physiological signal from a subject;

first calculation means for deriving at least one parameter sequence from at least one desired physiological signal belonging to the at least one physiological signal;

second calculation means for performing an index determination process configured to form a diagnostic index based on the at least one parameter sequence, wherein the diagnostic index serves as a measure of the clinical state of the subject and wherein the index determination process is configured to indicate the diagnostic index to a user;

quality enhancing means for monitoring at least one input signal and for enhancing the quality of the index determination process based on the at least one input signal, wherein the at least one input signal belongs to a group including the at least one physiological signal and the at least one parameter sequence.

36. A computer program product for improving the quality of a measurement of the clinical state of a subject, the computer program product comprising:

a first program code portion configured to monitor at least one input signal belonging to a group including at least one physiological signal acquired from a subject and at least one parameter sequence derived from at least one desired physiological signal belonging to the at least one physiological signal; and

a second program code portion responsive to the first program code portion and configured to enhance the quality of an index determination process configured to determine a diagnostic index based on the at least one parameter sequence, wherein the diagnostic index serves as a measure of the clinical state of the subject.

37. A computer program product according to claim 36, wherein the computer product further comprises a third program code portion configured to perform the index determination process.