Spatially Resolved Oxymetry

• US 20080242960A1
• Filed: 09/07/2006
• Published: 10/02/2008
• Est. Priority Date: 09/13/2005
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Nielsen, Tim, Koehler, Thomas
• Granted Patent: US 8,406,840 B2
• Time in Patent Office: Days
• US Class Current: 600/323
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes

Abstract

In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.

Claims

1. An optical examination apparatus (100) for optical examination of an object of interest (101), the optical examination apparatus comprising:

a detector unit (103) adapted for detecting first radiation and second radiation from the object of interest (101), resulting in first detection data and second detection data;

a determination unit (104) adapted for determining spatially resolved information relating to the object of interest (101) on the basis of the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest (101); and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest (101), which is different from the first oxygen concentration.

2. The optical examination apparatus (100) of claim 1,

further comprising an optical radiation source (102) adapted for emitting primary optical radiation to the object of interest (101).

3. The optical examination apparatus (100) of claim 1, wherein the determination unit (104) is adapted for reconstructing a two-dimensional or three-dimensional image of the object of interest (101) on the basis of the first detection data and the second detection data.

4. The optical examination apparatus (100) of claim 1,

wherein the first detection data corresponds to a systolic phase of the object of interest (101); and

wherein the second detection data corresponds to a diastolic phase of the object of interest (101).

5. The optical examination apparatus (100) of claim 4,

further comprising an electrocardiogram unit (105) adapted for acquiring electrocardiogram data of the object of interest (101) during the detection of the first radiation and the second radiation by the detector unit (103);

wherein the determination unit (104) is adapted for identifying the systolic phase and therefore the first detection data and for identifying the diastolic phase and therefore the second detection data on the basis of the electrocardiogram data.

6. The optical examination apparatus (100) of claim 1, wherein the determination unit (104) is adapted for reconstructing blood dynamics of the object of interest (101) on the basis of a temporal behaviour of the first radiation and the second radiation.

7. The optical examination apparatus (100) of claim 1,

wherein the detector unit (103) is adapted for detecting, as first detection data, first and second transmission data and, as second detection data, first and second reflection data.

8. The optical examination apparatus (100) of claim 1, adapted as an optical mammography apparatus.

9. The optical examination apparatus (100) of claim 1,

wherein the detector unit (103) is a spatially resolving detector.

10. The optical examination apparatus (100) of claim 1,

wherein the detector unit (103) is a frequency resolving detector or an energy resolving detector.

11. The optical examination apparatus (100) of claim 1,

wherein the detector unit (103) is a time resolving detector.

12. The optical examination apparatus (100) of claim 1,

wherein the information relating to the object of interest (101) is determined on the basis of a ratio of the first detection data and the second detection data.

13. A method of examining an object of interest (101) with an optical examination apparatus (100), the method comprising the steps of:

detecting first radiation and second radiation from the object of interest (101), resulting in first detection data and second detection data;

determining spatially resolved information relating to the object of interest (101) on the basis of the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest (101); and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest (101), which is different from the first oxygen concentration.

14. The method of claim 13, further comprising the step of:

acquiring electrocardiogram data of the object of interest (101) during the detection of the first radiation and the second radiation;

identifying the systolic phase and therefore the first detection data; and

identifying the diastolic phase and therefore the second detection data on the basis of the electrocardiogram data.

15. An image processing device for examining an object of interest (101) with an optical examination apparatus (100), the image processing device comprising:

a memory for storing first detection data and second detection data;

a determination unit (118), being adapted for;

determining spatially resolved information relating to the object of interest (101) on the basis of the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest (101); and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest (101), which is different from the first oxygen concentration.

16. A computer-readable medium (402), in which a computer program of examining an object of interest (101) with an optical examination apparatus (100) is stored which, when being executed by a processor (401), is adapted to carry out the steps of:

detecting first radiation and second radiation from the object of interest (101), resulting in first detection data and second detection data;

determining spatially resolved information relating to the object of interest (101) on the basis of the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest (101); and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest (101), which is different from the first oxygen concentration.

17. A program element of examining an object of interest (107), which, when being executed by a processor (401), is adapted to carry out the steps of:

detecting first radiation and second radiation from the object of interest (101), resulting in first detection data and second detection data;

determining spatially resolved information relating to the object of interest (101) on the basis of the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest (101); and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest (101), which is different from the first oxygen concentration.