System for in-vitro measurement of an analyte concentration

• US 20080242962A1
• Filed: 03/20/2008
• Published: 10/02/2008
• Est. Priority Date: 03/20/2007
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Menke, Andreas, Marquant, Michael, Niederhauser, Sandro, Roesicke, Bernd, Schoemaker, Michael, Schwind, Karin, Gaa, Otto, Bainczyk, Gregor, Scherer, Joerg, Lindegger, Stefan, Obermaier, Karin, Mueri, Martin
• Granted Patent: US 8,721,544 B2
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 2560/0209 adapted for power saving
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2560/0481 in implanted apparatus
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 90/98 using electromagnetic means, e.g. transponders

Abstract

The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. A base station carries the implantable sensor along with a signal processor, memory, and a transmitter. A display device is also disclosed that can receive the compressed measurement data from the base station for further processing and display.

Claims

1. A system for in-vitro measurement of blood glucose concentration in a human, comprising:

a base station comprising,

a base power source to supply power to components of the base station;

an implantable sensor for generating measurement signals that are correlated to a blood glucose concentration to be measured;

a pre-amplifier for amplifying the measurement signals;

a signal processor for processing the measurement signals to produce compressed measuring data that is compressed at least ten-times compared to the measurement signals,

base memory for storing compressed measurement data;

a transmitter for wireless transmission of the compressed measurement data; and

,

a display device comprising,

a display device power source that has greater capacity than the base power source to supply power to components of the display device;

a user input for inputting data into the display device;

a receiver for receiving the wireless transmission of the compressed measurement data from the base unit,

a microprocessor for processing the compressed measurement data to determine the blood glucose concentration;

a display for displaying blood glucose concentration.

2. The system as in claim 1 wherein the measurement signals are compressed through the selected sampling of the measurement signals.

3. The system as in claim 1 wherein the measurement signals are compressed through statistical techniques.

4. The system as in claim 3 wherein the statistical technique selects more than one measurement signal and determines the median of the more than one measurement signal.

5. The system as in claim 4 wherein the median of the more than one measurement signal is calculated by determining a slope of a line connecting each pair of measurement signals and calculating a median value of each slope of the line connecting each pair of measurement signals.

6. The system as in claim 5 wherein the median of the more than one measurement signal for each time interval is calculated from the median value of each slope of the line connecting each pair of measurement signals.

7. The system as in claim 1 wherein display device further comprises a blood glucose meter.

8. A base station for in-vitro measurement of blood glucose concentration in a human, comprising:

a base power source to supply power to components of the base station;

an implantable sensor for generating measurement signals that are correlated to a blood glucose concentration to be measured;

a pre-amplifier for amplifying the measurement signals;

a signal processor for processing the measurement signals to produce compressed measuring data that is compressed by at least a factor of ten compared to the measurement signals by selected sampling of the measurement signals and statistical processing of the measurement signals;

base memory for storing compressed measurement data; and

,

a transmitter for wireless transmission of the compressed measurement data.

9. The base station as in claim 8 wherein the statistical processing of the measurement signals selects more than one measurement signal and determines the median of the more than one measurement signal.

10. The base station as in claim 9 wherein the median of the more than one measurement signal is calculated by determining a slope of a line connecting each pair of measurement signals and calculating a median value of each slope of the line connecting each pair of measurement signals.

11. The base station as in claim 10 wherein the median other more than one measurement signal for each time interval is calculated from the median value of each slope of the line connecting each pair of measurement signals.

12. A base station for in-vitro measurement of blood glucose concentration in a human, comprising:

a base power source to supply power to components of the base station;

an implantable sensor for generating measurement signals that are correlated to a blood glucose concentration to be measured;

a pre-amplifier for amplifying the measurement signals;

means for signal processing for processing the measurement signals to produce compressed measuring data;

base memory for storing compressed measurement data; and

,

a transmitter for wireless transmission of the compressed measurement data.

13. A method of compressing data from in-vitro measurement of an analyte concentration in a human, comprising:

forming pairs of measurement signals from raw data generated for a lime interval;

determining a slope of a line connecting each pair of measurement signals;

calculating a median value of each slope of the line connecting each pair of measurement signals; and

,

calculating a compressed data value for each time interval from the median value of each slope of the line connecting each pair of measurement signals and the compressed data value of a preceding time interval.

14. The method as in claim 13, further comprising,

disregarding raw data that are a substantial deviation from other raw data.

15. The method as in claim 13, further comprising,

determining raw data consecutively over constant time intervals using time marks including a date and a time.