Method for Inhibiting Platelet Interaction with Biomaterial Surfaces
First Claim
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1. A method for passivating a biomaterial surface, said method comprising exposing said biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.
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Abstract
A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.
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Citations
25 Claims
- 1. A method for passivating a biomaterial surface, said method comprising exposing said biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.
- 4. A passivated biomaterial surface formed from a biomaterial surface exposed to therapeutic electrical energy in the presence of blood or plasma.
- 8. A method for passivating a biomaterial surface, said method comprising modifying proteinaceous material disposed at said biomaterial surface.
- 11. A method for passivating a biomaterial surface, said method comprising depositing modified proteinaceous material at said biomaterial surface.
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13. A method for passivating a biomaterial surface, said method comprising:
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(a) exposing a quantity of blood or plasma to therapeutic electrical energy; and (b) subsequent to step (a), depositing proteinaceous material from said quantity of blood or plasma on said biomaterial surface. - View Dependent Claims (14)
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15. A passivated biomaterial surface including conformationally altered fibrinogen.
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16. A biomaterial, comprising:
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(a) a first surface; and (b) a conformationally altered fibrinogen disposed at said first surface.
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- 17. A method for inhibiting aggregation of blood platelets at a biomaterial surface, said method comprising exposing said biomaterial to therapeutic electrical energy in the presence of blood or plasma.
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22. A method for inhibiting blood platelet adhesion to a biomaterial surface, said method comprising promoting conformationally modified fibrinogen at said biomaterial surface.
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23. A biomaterial surface effective in inhibiting blood platelet adhesion thereto, said biomaterial surface including conformationally modified fibrinogen.
- 24. A method for passivating a biomaterial surface, said method comprising modulating the preferential adsorption of blood proteins to said biomaterial surface.
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