Implantable medical articles having pro-healing coatings

• US 20080243243A1
• Filed: 07/03/2007
• Published: 10/02/2008
• Est. Priority Date: 07/07/2006
• Status: Abandoned Application

• Current Assignee: David E. Babcock, David L. Clapper, Joseph A. Chinn, Stuart K. Williams
• Original Assignee: David E. Babcock, David L. Clapper, Joseph A. Chinn, Stuart K. Williams
• Inventors: Williams, Stuart K., Chinn, Joseph A., Babcock, David E., Clapper, David L.
• Application Number:
  US11/824,908
• Publication Number:
  US 20080243243A1
• Time in Patent Office: Days
• US Class Current: 623/1.47
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/0029 using an intermediate layer of polymer
• CPC Class Codes: A61L 33/122 Collagen
• CPC Class Codes: A61L 33/128 Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

Coatings including adhesion factors for the surfaces of implantable medical articles are disclosed. The coatings are used to improve the function of the device by promoting a pro-healing response following implantation. The coatings can modulate endothelialization of the article surface to reduce the risk of adverse tissue responses that may reduce the functionality of the device.

Claims

1. A coated intravascular medical device comprising:

a body member comprising a metal or metal alloy and having a body member surface, and

a coating on the body member surface comprising;

a first layer that is in contact with tissue or body fluid, wherein the first layer comprises, predominantly, an adhesion factor and a photogroup; and

a second layer located between the body member surface and the first layer, the second layer comprising a polymeric material, and wherein the photogroup bonds the adhesion factor to the polymeric material.

2. The coated intravascular medical device of claim 1 wherein the photogroup is pendent from the adhesion factor.

3. The coated intravascular medical device of claim 1 wherein the adhesion factor comprises collagen.

4. The coated intravascular medical device of claim 1 wherein the polymeric material comprises poly(para-xylylene).

5. The coated intravascular medical device of claim 1 having a body member in the form of a stent.

6. A coated intravascular medical device comprising:

a body member having a body member surface, and

a bioactive agent-releasing coating on the body member surface comprising;

a first layer that is in contact with tissue or body fluid, wherein the first layer comprises, predominantly, a adhesion factor and a photogroup; and

a second layer located between the body member surface and the first layer, the second layer comprising a polymeric material and a bioactive agent, and wherein the photogroup bonds the adhesion factor to the polymeric material.

7. The coated intravascular medical device of claim 6 wherein the polymeric material of the second layer comprises a hydrophobic polymer.

8. The coated intravascular medical device of claim 6 wherein the polymeric material of the second layer comprises a degradable polymer.

9. A method for improving the endothelialization of a surface of an implantable medical article, the method comprising steps of

providing a medical article with a coating comprising a polymeric material, a bioactive agent, an adhesion factor, and a photogroup that bonds the adhesion factor to the polymeric material;

and

implanting the coated medical article in a subject, wherein the coating promotes a level of endothelialization in the subject that is greater than a level of endothelialization observed without the adhesion factor and photogroup.

10. A method for modulating the endothelialization of a surface of an implantable medical article, the method comprising steps of

obtaining information regarding the endothelialization of a surface of the medical article, wherein the medical article has a first level of endothelialization when implanted into a subject after a period of time, and the first level of endothelialization is associated with an undesirable tissue response;

providing a medical article with a coating comprising at least one adhesion factor and a photogroup to form a coated medical article; and

implanting the coated medical article in a subject, wherein the coating promotes a second level of endothelialization in the subject that is less than the first level of endothelialization after the period of time.

11. The method of claim 10 wherein the step of obtaining, the undesirable tissue response is smooth muscle cell hyperproliferation.

12. The method of claim 10 wherein the subject is a human and the period of time is about two weeks, or greater than two weeks.

13. The method of claim 10 wherein the period of time is about four weeks.

14. The method of claim 10 wherein the step of providing comprises providing a coating to the medical article that comprises an adhesion factor selected from collagens and laminins, active portions thereof, or binding members thereof.

15. The method of claim 14 wherein the step of providing comprises providing a coating to the medical article that comprises collagen I, active portions thereof, or binding members thereof.

16. The method of claim 10 wherein the step of providing comprises providing a coating to an intraluminal prosthesis.

17. The method of claim 14 wherein the step of providing comprises providing a coating to an intravascular prosthesis.

18. The method of claim 10 wherein the step of implanting is performed by delivering the medical article to an intravascular location in the subject and maintaining for a period of time sufficient to cause the formation of an endothelial layer of cells on a surface of the medical article.

19. A coated intravascular medical device comprising a body member comprising a bioresorbable material, and a coating on the bioresorbable body member, the coating comprising adhesion factor and a photogroup, wherein the photogroup allows the adhesion factor to form a coated layer on the surface of the body member.

20. The coated intravascular medical device of claim 19 wherein bioresorbable material comprises a biodegradable polymer and the photogroups bond the adhesion factor to the biodegradable polymer.

21. The coated intravascular medical device of claim 19 wherein photogroups bond adhesion factor together.