METHODS AND COMPOSITIONS FOR DIRECTED MICROWAVE CHEMISTRY
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Abstract
The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen molecules, which may be very similar in structure to the chosen reactant. The reactions may be stoichiometric or catalytic.
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Citations
128 Claims
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1-77. -77. (canceled)
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78. A method for detecting a chemical reaction of a reactant, said method comprising:
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(a) contacting said reactant with a solid composite, said composite comprising a material susceptible to microwave heating and a specific binding molecule for the reactant, said contacting being conducted under conditions sufficient to allow said reactant to bind to said specific binding molecule of said composite via a biospecific interaction, wherein said specific binding molecule is thermally proximal to said solid material to thereby provide the reactant thermally proximal to the solid material upon binding; (b) applying an electromagnetic field of a wavelength of between 1 cm and 100 m to said composite, resulting in microwave heating of said solid material, wherein said heated solid material heats said thermally proximal reactant, wherein said chemical reaction is accelerated by said heating of said reactant; and (c) detecting a physical or chemical property associated with said chemical reaction. - View Dependent Claims (79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103)
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104. A method for detecting a chemical reaction of a reactant, said method comprising:
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(a) contacting a reactant-containing solution with a solid composite, said composite comprising a specific binding molecule for the reactant and a material susceptible to microwave heating, said contacting being under conditions sufficient to allow said reactant to bind to said specific binding molecule of said composite via a biospecific interaction, thereby forming a composite-reactant complex, wherein said composite-reactant complex is thermally proximal to said solid material; (b) separating said composite-reactant complex from the solution; (c) applying an electromagnetic field of a wavelength of between 1 cm and 100 m to said composite of said composite-reactant complex, resulting in microwave heating of the solid material of said complex,—
whereby said heated solid material heats said reactant of said thermally proximal composite-reactant complex, wherein said chemical reaction is accelerated by said heating of said reactant of said composite-reactant complex; and(d) detecting a physical or chemical property associated with said chemical reaction. - View Dependent Claims (105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128)
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Specification