MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY SUBSTRATES HAVING LOW VOLUME MATRIX ARRAY ELEMENTS
First Claim
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1. A substrate for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis, which comprises a surface having an array of spots, whereineach spot comprises 3-hydroxypicolinic acid matrix resulting from the deposition of a reproduced, defined and controlled nanoliter scale volume and no analyte;
- the substrate is a flat chip; and
the center of each spot is about 2.25 millimeters or less from the center of an adjacent spot.
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Abstract
Provided herein are substrates for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis. Each spot includes 3-hydroxypicolinic acid matrix and no analyte.
101 Citations
9 Claims
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1. A substrate for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis, which comprises a surface having an array of spots, wherein
each spot comprises 3-hydroxypicolinic acid matrix resulting from the deposition of a reproduced, defined and controlled nanoliter scale volume and no analyte; -
the substrate is a flat chip; and the center of each spot is about 2.25 millimeters or less from the center of an adjacent spot. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification