METHOD AND APPARATUS FOR ENHANCEMENT AND QUALITY IMPROVEMENT OF ANALYTE MEASUREMENT SIGNALS

• US 20080249393A1
• Filed: 04/04/2007
• Published: 10/09/2008
• Est. Priority Date: 04/04/2007
• Status: Abandoned Application

• Current Assignee: OrSense Ltd.
• Original Assignee: OrSense Ltd.
• Inventors: Kleinman, Yossie, Finarov, Alexander
• Application Number:
  US11/696,715
• Publication Number:
  US 20080249393A1
• Time in Patent Office: Days
• US Class Current: 600/391
• CPC Class Codes: A61B 5/02241 of small dimensions, e.g. adapted to fingers
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts

Abstract

While measuring analytes in an object, movements between the object and a device that is taking the measurement may adversely effect the accuracy of the measurements. A probe that engages an object includes a sticky surface that comes into contact with the object to alleviate the relative movement between the probe and the object. The sticky substance can be applied in a variety of manners and embodiments and in general, helps to reduce the relative movement. In addition, the probe may include the ability to apply pressure to the object. The pressure can range from a slight pressure to help reduce relative movement to a pressure that exceeds systolic pressure, thereby constricting the flow of blood through the object.

Claims

1. A probe for application to an object for non-invasive analyte measurement, said probe comprising:

a) a body with at least one sticky surface, and

b) a source of radiation and a detector built into said body.

2. The probe according to claim 1, wherein said source of radiation and detector are operable to measure a blood and tissue analyte.

3. The probe according to claim 1, wherein said body comprises one of a pressure development article, a multilayer resilient structure, or a combination of both of them.

4. The probe according to claim 1, wherein said sticky surface engages said object.

5. The probe according to claim 1, wherein said sticky surface restricts relative movements between said probe and said object.

6. The probe according to claim 1, wherein said sticky surface is one of a silicone layer having a hardness of less than 15 Shorr surface, a coating, a plurality of micron size columns, or a temporarily sprayed coating.

7. The probe according to claim 1, wherein said sticky surface is a cleanable surface.

8. The probe according to claim 1, wherein said source of radiation is a source of red and infrared radiation.

9. The probe according to claim 1, wherein the resilient structure of said body is a multilayer structure, and wherein at least one of said layers develops and supports application of pressure to said object.

10. The probe according to claim 1, wherein the resilient structure of said body is a multilayer structure, and wherein at least one of said layers has at least a section of a surface possessing sticky properties.

11. The probe according to claim 1, wherein at least one of the layers of the multilayer structure of said body is armored by one of external or internal armor.

12. The probe according to claim 1, wherein said body is a lightproof thimble-like or sleeve-like body.

13. The probe according to claim 1, wherein operation of the pressure development article of said probe includes operation in occlusion-release mode, and wherein said occlusion mode develops pressure higher than systolic pressure.

14. An apparatus for determination of a physiological parameter of a subject, said apparatus comprising:

a) a probe for receiving a measurement object, wherein the surface of said probe engaging the object is a sticky surface, and

b) a control and processing unit.

15. The apparatus according to claim 14, wherein said sticky surface restricts relative movements between said probe and the object.

16. The apparatus according to claim 14, wherein said probe is one of a resilient structure, a pressure development article, or a combination of both.

17. The apparatus according to claim 14, wherein a source of red and infrared radiation and a detector are built into said probe.

18. The apparatus according to claim 14, wherein said probe includes a pressure development article and operation of said article includes operation in occlusion-release mode.

19. The apparatus according to claim 14, wherein the pressure development article of said probe develops pressure exceeding systolic pressure.

20. The apparatus according to claim 14, wherein said physiological parameter is one of tissue or blood parameters.

21. The apparatus according to claim 14, wherein said physiological parameter is concentration of one of hemoglobin, hematocrit, glucose, bilirubin, oxygen saturation, cholesterol and albumin.

22. The apparatus according to claim 14, wherein said control and processing unit includes a display.

23. A method of a non-invasive analyte concentration measurement, said method comprising:

a) applying to a measurement object a probe with a surface engaging said object being a sticky surface; and

b) operating said probe to perform the measurement of said analyte of interest.

24. The method according to claim 23, wherein said measurement includes operation of said probe in occlude-release mode.

25. The method according to claim 23, wherein the operation of said probe in said occlude-release mode develops pressure that exceeds systolic pressure and temporarily ceases blood flow in said object.

26. The method according to claim 23, wherein operation of said probe includes operation of a source of red and infrared radiation that is built into said probe.

27. The method according to claim 23, wherein said analyte of interest is a tissue and blood analyte.

28. The method according to claim 23, wherein said analyte of interest is concentration of one of hemoglobin, hematocrit, glucose, bilirubin, oxygen saturation, cholesterol and albumin.

29. The method according to claim 23, wherein said engagement of the sticky surface with the object reduces the relative movement between said object and said structure to alleviate movement that would have a substantial effect on said concentration measurements.

30. The method according to claim 23, wherein said probe communicates the measurement data to a control and processing unit.

31. A method of reducing motion artifacts in a non-invasive analyte measurement, said method comprising:

a) applying to a measurement object a probe, wherein a surface of said probe that engages the object is a sticky surface;

b) performing the measurement of said analyte of interest, and

c) reducing said motion artifacts by restricting with the help of said sticky surface said object-probe relative movements.

32. The method according to claim 31, wherein said measurement includes operation of a source of red and infrared radiation that is built into said probe.

33. The method according to claim 31, wherein said measurement includes the application of pressure to create an occlude-release mode and wherein the pressure in said occlude-release mode exceeds systolic pressure, whereby blood flow in said object is temporarily ceased.

34. The method according to claim 31, wherein said analyte of interest is a concentration of one of hemoglobin, hematocrit, glucose, bilirubin, oxygen saturation, cholesterol and albumin.

35. A method of reducing motion artifacts in a non-invasive analyte concentration measurement, said method characterized in that a sticky surface of a probe reduces said artifacts by engaging at least a section the object of measurement.

36. A method of a non-invasive analyte concentration measurement, said method comprising:

a) engaging a surface of a probe with a surface of a measurement object and wherein at least one of said surfaces is a sticky surface; and

b) operating said probe to perform the measurement of analyte of interest.

37. The method according to claim 36, wherein said measurement includes operation of said probe in occlusion-release mode and wherein said mode develops pressure that exceeds systolic pressure and temporarily ceases blood flow in said object.

38. The method according to claim 36, wherein said measurement includes operation of a source of red and infrared radiation built into said probe.

39. The method according to claim 36, wherein said analyte of interest is a concentration of one of hemoglobin, hematocrit, glucose, bilirubin, oxygen saturation, cholesterol and albumin.

40. The method according to claim 36, wherein the engagement with said at least one sticky surface reduces the relative movement between said object and said probe in such a manner to allevate movement that may have an adverse effect on the accuracy of said analyte concentration measurements.

41. The method according to claim 36, wherein said at least one sticky surface is the surface of the object.

42. A probe for non-invasive optical analyte measurement, said probe characterized in that at least one of the surfaces of the probe engaging the measurement object is a sticky surface.